MEDI 75-Design and synthesis of 3-phenylsulfonylmethyl cyclohexylaminobenzamide-derived inhibitors of CC chemokine receptor 2 (CCR2)

被引:0
|
作者
Xiao, Zili [1 ]
Delucca, George V. [1 ]
Cherney, Robert J. [1 ]
Shi, Qing [1 ]
Mo, Ruowei [1 ]
Santella, Joseph B. [1 ]
Tebben, Andrew J. [2 ]
Cvijic, Mary Ellen [3 ]
Zhao, Qihong [4 ]
Barrish, Joel C. [1 ]
Carter, Percy H. [1 ]
Yang, Michael G. [1 ]
机构
[1] Bristol Myers Squibb Res & Dev, Discovery Chem, Princeton, NJ 08543 USA
[2] Bristol Myers Squibb Co, Comp Assisted Drug Design, Princeton, NJ 08543 USA
[3] Bristol Myers Squibb Co, Lead Evaluat, Res & Dev, Princeton, NJ 08543 USA
[4] Bristol Myers Squibb Co, Immunol Biol, Res & Dev, Princeton, NJ 08543 USA
关键词
D O I
暂无
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
75-MEDI
引用
收藏
页数:1
相关论文
共 50 条
  • [1] Synthesis of 3-phenylsulfonylmethyl cyclohexylaminobenzamide-derived antagonists of CC chemokine receptor 2 (CCR2)
    Yang, Michael G.
    Xiao, Zili
    Shi, Qing
    Cherney, Robert J.
    Tebben, Andrew J.
    De Lucca, George V.
    Santella, Joseph B., III
    Mo, Ruowei
    Cvijic, Mary Ellen
    Zhao, Qihong
    Barrish, Joel C.
    Carter, Percy H.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2012, 22 (03) : 1384 - 1387
  • [2] Design and synthesis of 3-alkylsulfonylmethyl cyclohexylaminobenzamide-derived inhibitors of CC chemokine receptor 2 (CCR2)
    Yang, Michael G.
    Batt, Douglas G.
    Cherney, Robert J.
    Mandlekar, Sandhya
    Cvijic, MaryEllen
    Zhao, Qihong
    Barrish, Joel C.
    Carter, Percy H.
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2010, 240
  • [3] Design and synthesis of 2-substituted cyclohexylaminobenzamide-derived inhibitors of CC Chemokine Receptor 2 (CCR2)
    Yang, Michael G.
    Barrish, Joel C.
    Batt, Douglas G.
    Brown, Gregory
    Chen, Bang-Chi
    Cherney, Robert J.
    Cvijic, MaryEllen
    Delucca, George V.
    Duncia, John V.
    Gardner, Daniel S.
    Santella, Joseph B.
    Shi, Qing
    Srivastava, Anurag
    Wang, Bei
    Xiao, Zili
    Zhao, Qihong
    Zhao, Rulin
    Carter, Percy H.
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2013, 245
  • [4] Capped diaminopropionamide-glycine dipeptides are inhibitors of CC chemokine receptor 2 (CCR2)
    Carter, Percy H.
    Brown, Gregory D.
    Friedrich, Sarah R.
    Cherney, Robert J.
    Tebben, Andrew J.
    Lo, Yvonne C.
    Yang, Gengjie
    Jezak, Heather
    Solomon, Kimberly A.
    Scherle, Peggy A.
    Decicco, Carl P.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2007, 17 (19) : 5455 - 5461
  • [5] Synthesis and biological evaluation of spirocyclic antagonists of CCR2 (chemokine CC receptor subtype 2)
    Strunz, Ann Kathrin
    Zweemer, Annelien J. M.
    Weiss, Christina
    Schepmann, Dirk
    Junker, Anna
    Heitman, Laura H.
    Koch, Michael
    Wuensch, Bernhard
    BIOORGANIC & MEDICINAL CHEMISTRY, 2015, 23 (14) : 4034 - 4049
  • [6] The presence of leukocyte CC-Chemokine receptor 2 (CCR2) in CCR2 knockout mice promotes atherogenesis
    Jian, G
    Van Eck, M
    von der Thüsen, JH
    Maeda, N
    Benson, GM
    Groot, PH
    Van Berkel, TJ
    CIRCULATION, 2003, 108 (17) : 65 - 65
  • [7] Inducing Receptor Degradation as a Novel Approach to Target CC Chemokine Receptor 2 (CCR2)
    Zacarias, Natalia V. Ortiz
    Roth, Sascha
    Broekhuis, Jeremy D.
    van der Es, Daan
    Moreau, Kevin
    Heitman, Laura H.
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2024, 25 (16)
  • [8] Discovery and profile of cyclopentylamines as inhibitors of chemokine receptor CCR2
    Winters, Michael P.
    O'Neill, John
    Hou, Cuifen
    Johnson, Dana
    Sui, Zhihua
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2012, 244
  • [9] Inducing receptor degradation as a novel approach to target CC chemokine receptor 2 (CCR2)
    Zacarias, Natalia Ortiz
    Broekhuis, Jeremy
    van der Es, Daan
    Heitman, Laura H.
    BRITISH JOURNAL OF PHARMACOLOGY, 2023, 180 : 657 - 658
  • [10] Novel, orally bioavailable γ-aminoamide CC chemokine receptor 2 (CCR2) antagonists
    Pasternak, Alexander
    Marino, Dominick
    Vicario, Pasquale P.
    Ayala, Julia Marie
    Cascierri, Margaret A.
    Parsons, William
    Mills, Sander G.
    MacCoss, Malcolm
    Yang, Lihu
    JOURNAL OF MEDICINAL CHEMISTRY, 2006, 49 (16) : 4801 - 4804