Catalytic Asymmetric Allylic Alkylation with Arylfluoroacetonitriles

被引：9

作者：

Sripada, Archita ^{[1
]}

Wolf, Christian ^{[1
]}

机构：

[1] Georgetown Univ, Dept Chem, Washington, DC 20057 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2022年 / 87卷 / 17期

基金：

美国国家卫生研究院;

关键词：

QUATERNARY STEREOGENIC CENTERS; STEREOSELECTIVE-SYNTHESIS; MANNICH REACTIONS; EFFICIENT ACCESS; CONSTRUCTION;

D O I：

10.1021/acs.joc.2c01414

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A palladium(phosphinoxazoline) catalyzed method for asymmetric allylic alkylation of alpha-aryl-alpha-fluoroacetonitriles is introduced. This reaction achieves C-C bond formation and incorporation of two adjacent chirality centers with moderate to good yields, high enantioselectivities, and up to 15:1 dr.

引用

页码：11880 / 11887

页数：8

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