Mechanisms of antifungal and anti-aflatoxigenic properties of essential oil derived from turmeric (Curcuma longa L.) on Aspergillus flavus

被引：224
|
作者：
Hu, Yichen [1 ,2 ]
Zhang, Jinming [3 ]
Kong, Weijun [2 ]
Zhao, Gang [1 ]
Yang, Meihua [2 ]
机构：
[1] Chengdu Univ, Sch Pharm & Bioengn, Chengdu 610106, Peoples R China
[2] Chinese Acad Med Sci, Key Lab Bioact Subst & Resources Utilizat Chinese, Inst Med Plant Dev, Minist Educ,Peking Union Med Coll, Beijing 100193, Peoples R China
[3] Chengdu Univ Tradit Chinese Med, Sch Pharm, Chengdu 611137, Peoples R China
来源：
FOOD CHEMISTRY | 2017年 / 220卷
基金：
中国国家自然科学基金;
关键词：
Aspergillus flavus; Turmeric; Essential oil; Antifungal; Aflatoxin; ANTIBACTERIAL; EFFICACY; LEAVES; FOODS;
D O I：
10.1016/j.foodchem.2016.09.179
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
The antifungal activity and potential mechanisms in vitro as well as anti-aflatoxigenic efficiency in vivo of natural essential oil (EO) derived from turmeric (Curcuma longa L.) against Aspergillus flavus was intensively investigated. Based on the previous chemical characterization of turmeric EO by gas chromatography-mass spectrometry, the substantially antifungal activities of turmeric EO on the mycelial growth, spore germination and aflatoxin production were observed in a dose-dependent manner. Furthermore, these antifungal effects were related to the disruption of fungal cell endomembrane system including the plasma membrane and mitochondria, specifically i.e. the inhibition of ergosterol synthesis, mitochondrial ATPase, malate dehydrogenase, and succinate dehydrogenase activities. Moreover, the down-regulation profiles of turmeric EO on the relative expression of mycotoxin genes in aflatoxin biosynthetic pathway revealed its anti-aflatoxigenic mechanism. Finally, the suppression effect of fungal contamination in maize indicated that turmeric EO has potential as an eco-friendly antifungal agent. (C) 2016 Elsevier Ltd. All rights reserved.
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页码：1 / 8
页数：8
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