Biocompatibility of ferritin-based nanoparticles as targeted MRI contrast agents

被引:34
|
作者
Charlton, Jennifer R. [1 ]
Pearl, Valeria M. [1 ]
Denotti, Anna R. [2 ]
Lee, Jonathan B. [3 ]
Swaminathan, Sundararaman [4 ,5 ]
Scindia, Yogesh M. [4 ,5 ]
Charlton, Nathan P. [6 ]
Baldelomar, Edwin J. [7 ]
Beeman, Scott C. [8 ]
Bennett, Kevin M. [9 ]
机构
[1] Univ Virginia, Dept Pediat, Div Nephrol, Charlottesville, VA USA
[2] Univ Cagliari, Osped Reg Microcitemie, Dept Pediat, Cagliari, Italy
[3] Eastern Virginia Med Sch, Dept Pediat, Norfolk, VA USA
[4] Univ Virginia, Ctr Immun Inflammat & Regenerat Med, Charlottesville, VA USA
[5] Dept Med, Div Nephrol, Charlottesville, VA USA
[6] Univ Virginia, Dept Emergency Med, Div Med Toxicol, Charlottesville, VA USA
[7] Univ Hawaii Manoa, Dept Phys, Honolulu, HI USA
[8] Univ Hawaii Manoa, Dept Biol, Honolulu, HI USA
[9] Washington Univ, Sch Med, Dept Radiol, St Louis, MO USA
基金
美国国家卫生研究院;
关键词
Ferritin; Magnetic resonance imaging; Toxicity; Nephron number; Kidney; Cationic ferritin; CATIONIZED FERRITIN; IMAGING PROBE; MAGNETOFERRITIN; IRON; BIODISTRIBUTION; TURNOVER; MEDICINE; REPORTER; KIDNEYS; DESIGN;
D O I
10.1016/j.nano.2016.03.007
中图分类号
TB3 [工程材料学];
学科分类号
0805 ; 080502 ;
摘要
Ferritin is a naturally occurring iron storage protein, proposed as a clinically relevant nanoparticle with applications as a diagnostic and therapeutic agent. Cationic ferritin is a targeted, injectable contrast agent to measure kidney microstructure with MRI. Here, the toxicity of horse spleen ferritin is assessed as a step to clinical translation. Adult male mice received cationic, native and high dose cationic ferritin (CF, NF, or HDCF) or saline and were monitored for 3 weeks. Transient weight loss occurred in the ferritin groups with no difference in renal function parameters. Ferritin-injected mice demonstrated a lower serum iron 3 weeks after administration. In ferritin-injected animals pre-treated with hydrocortisone, there were no structural or weight differences in the kidneys, liver, lung, heart, or spleen. This study demonstrates a lack of significant detrimental effects of horse-derived ferritin-based nanoparticles at MRI-detectable doses, allowing further exploration of these agents in basic research and clinical diagnostics. (C) 2016 Elsevier Inc. All rights reserved.
引用
收藏
页码:1735 / 1745
页数:11
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