Inorganic Nanoparticles for MRI Contrast Agents

被引:1463
|
作者
Na, Hyon Bin [1 ]
Song, In Chan [2 ]
Hyeon, Taeghwan [1 ]
机构
[1] Seoul Natl Univ, Sch Chem & Biol Engn, Natl Creat Res Initiat Ctr Oxide Nanocrystalline, Seoul 151744, South Korea
[2] Seoul Natl Univ Hosp, Dept Radiol, Seoul 110744, South Korea
关键词
IRON-OXIDE NANOPARTICLES; PROTON CHEMICAL-EXCHANGE; IN-VIVO TRACKING; MAGNETIC NANOPARTICLES; QUANTUM DOTS; SATURATION-TRANSFER; DENDRITIC CELLS; PARACEST AGENTS; PHASE-TRANSFER; GENE DELIVERY;
D O I
10.1002/adma.200802366
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Various inorganic nanoparticles have been used as magnetic resonance imaging (MRI) contrast agents due to their unique properties, such as large surface area and efficient contrasting effect. Since the first use of super-paramagnetic iron oxide (SPIO) as a liver contrast agent, nanoparticulate MRI contrast agents have attracted a lot of attention. Magnetic iron oxide nanoparticles have been extensively used as MRI contrast agents due to their ability to shorten T2* relaxation times in the liver, spleen, and bone marrow. More recently, uniform ferrite nanoparticles with high crystallinity have been successfully employed as new T2 MRI contrast agents with improved relaxation properties. Iron oxide nanoparticles functionlized with targeting agents have been used for targeted imaging via the site-specific accumulation of nanoparticles at the targets of interest. Recently, extensive research has been conducted to develop nanoparticle-based T1 contrast agents to over-come the drawbacks of iron oxide nanoparticle-based negative T2 contrast agents. In this report, we summarize the recent progress in inorganic nanoparticle-based MRI contrast agents.
引用
收藏
页码:2133 / 2148
页数:16
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