Mathematical modeling of the hypothalamic-pituitary-adrenal system activity

被引：53
|
作者：
Jelic, S
Cupic, Z
Kolar-Anic, L
机构：
[1] Vinca Inst Nucl Sci, Dept Theoret Phys & Phys Condensed Matter 020 2, Belgrade 11001, Serbia Monteneg
[2] Inst Chem Technol & Met, Dept Catalysis & Chem Engn, Belgrade 11000, Serbia Monteneg
[3] Univ Belgrade, Fac Phys Chem, Belgrade 11001, Serbia Monteneg
来源：
MATHEMATICAL BIOSCIENCES | 2005年 / 197卷 / 02期
关键词：
HPA system; cortisol; mathematical model; non-linear dynamics; stability analysis;
D O I：
10.1016/j.mbs.2005.06.006
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Mathematical modeling has proven to be valuable in understanding of the complex biological systems dynamics. In the present report we have developed an initial model of the hypothalamic-pitutary-adrenal system self-regulatory activity. A four-dimensional non-linear differential equation model of the hormone secretion was formulated and used to analyze plasma cortisol levels in humans. The aim of this work was to explore in greater detail the role of this system in normal, homeostatic, conditions, since it is the first and unavoidable step in further understanding of the role of this complex neuroendocrine system in pathophysiological conditions. Neither the underlying mechanisms nor the physiological significance of this system are fully understood yet. (c) 2005 Elsevier Inc. All rights reserved.
引用
收藏
页码：173 / 187
页数：15
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