Factors Associated with Worse Lung Function in Cystic Fibrosis Patients with Persistent Staphylococcus aureus

被引:57
|
作者
Junge, Sibylle [1 ]
Göerlich, Dennis [2 ]
den Reijer, Martijn [3 ]
Wiedemann, Baerbel [4 ]
Tuemmler, Burkhard [5 ]
Ellemunter, Helmut [6 ]
Duebbers, Angelika [7 ]
Kuester, Peter [8 ]
Ballmann, Manfred [9 ]
Koerner-Rettberg, Cordula [9 ]
Grosse-Onnebrink, Joerg [10 ]
Heuer, Eberhardt [11 ]
Sextro, Wolfgang [11 ]
Mainz, Jochen G. [12 ]
Hammermann, Jutta [13 ]
Riethmueller, Joachim [14 ]
Graepler-Mainka, Ute [14 ]
Staab, Doris [15 ]
Wollschlaeger, Bettina [16 ]
Szczepanski, Ruediger [17 ]
Schuster, Antje [18 ]
Tegtmeyer, Friedrich-Karl [19 ]
Sutharsan, Sivagurunathan [20 ]
Wald, Alexandra [21 ]
Nofer, Jerzy-Roch [22 ]
van Wamel, Willem [3 ]
Becker, Karsten [23 ]
Peters, Georg [23 ]
Kahl, Barbara C. [23 ]
机构
[1] Clin Paediat Pulmonol Allergol & Neonatol, Hannover, Germany
[2] Univ Hosp Munster, Inst Biostat & Clin Res, Munster, Germany
[3] Erasmus MC, Dept Med Microbiol & Infect Dis, Rotterdam, Netherlands
[4] Tech Univ Dresden, Inst Med Informat & Biometr, Dresden, Germany
[5] Hannover Med Sch, Clin Paediat Pulmonol Allergol & Neonatol, Clin Res Grp, Hannover, Germany
[6] Med Univ Innsbruck, Dept Child & Adolescent Hlth, CF Ctr Innsbruck, Innsbruck, Austria
[7] Univ Hosp Munster, Dept Paediat, Munster, Germany
[8] Clemenshosp Munster, Dept Paediat, Munster, Germany
[9] Ruhr Univ, Paediat Clin, St Josef Hosp, Bochum, Germany
[10] Univ Hosp Essen, Dept Paediat, Essen, Germany
[11] Kinderarztl Ambulanz, Hamburg, Germany
[12] Jena Univ Hosp, Dept Paediat, CF Ctr, Jena, Germany
[13] Univ Clin Dresden, Dept Paediat, Dresden, Germany
[14] Univ Clin Tubingen, Dept Pediat, Tubingen, Germany
[15] Charite Univ Med Berlin, Dept Paediat Pulmonol & Immunol, Campus Virchow Klinikum, Berlin, Germany
[16] Univ Hosp Halle, Halle, Germany
[17] Childrens Hosp Osnabruck, Osnabruck, Germany
[18] Univ Dusseldorf, Dept Paediat, Dusseldorf, Germany
[19] Pk Schonefeld Clin, Kassel, Germany
[20] Ruhrlandklin, Essen, Germany
[21] Univ Clin Leipzig, Leipzig, Germany
[22] Univ Hosp Munster, Ctr Lab Med, Munster, Germany
[23] Univ Hosp Munster, Inst Med Microbiol, Munster, Germany
来源
PLOS ONE | 2016年 / 11卷 / 11期
关键词
SMALL-COLONY VARIANTS; C-REACTIVE PROTEIN; PSEUDOMONAS-AERUGINOSA; NASAL CARRIAGE; STENOTROPHOMONAS-MALTOPHILIA; FEV1; DECLINE; RISK-FACTORS; INFECTION; CHILDREN; EXACERBATIONS;
D O I
10.1371/journal.pone.0166220
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Background Staphylococcus aureus is an important pathogen in cystic fibrosis (CF). However, it is not clear which factors are associated with worse lung function in patients with persistent S. aureus airway cultures. Our main hypothesis was that patients with high S. aureus density in their respiratory specimens would more likely experience worsening of their lung disease than patients with low bacterial loads. Methods Therefore, we conducted an observational prospective longitudinal multi-center study and assessed the association between lung function and S. aureus bacterial density in respiratory samples, co-infection with other CF-pathogens, nasal S. aureus carriage, clinical that no competing interests exist. status, antibiotic therapy, IL-6- and IgG-levels against S. aureus virulence factors. Results 195 patients from 17 centers were followed; each patient had an average of 7 visits. Data were analyzed using descriptive statistics and generalized linear mixed models. Our main hypothesis was only supported for patients providing throat specimens indicating that patients with higher density experienced a steeper lung function decline (p<0.001). Patients with exacerbations (n = 60), S. aureus small-colony variants (SCVs, n = 84) and co-infection with Stenotrophomonas maltophilia (n = 44) had worse lung function (p = 0.0068; p = 0.0011; p = 0.0103). Patients with SCVs were older (p = 0.0066) and more often treated with trimethoprim/sulfamethoxazole (p = 0.0078). IL-6 levels positively correlated with decreased lung function (p<0.001), S. aureus density in sputa (p = 0.0016), SCVs (p = 0.0209), exacerbations (p = 0.0041) and co-infections with S. maltophilia (p = 0.0195) or A. fumigatus (p = 0.0496). Conclusions In CF-patients with chronic S. aureus cultures, independent risk factors for worse lung function are high bacterial density in throat cultures, exacerbations, elevated IL-6 levels, presence of S. aureus SCVs and co-infection with S. maltophilia.
引用
收藏
页数:18
相关论文
共 50 条
  • [21] Impact of Staphylococcus aureus on the pathogenesis of chronic cystic fibrosis lung disease
    Kahl, Barbara C.
    INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY, 2010, 300 (08) : 514 - 519
  • [22] Factors in childhood associated with lung function decline to adolescence in cystic fibrosis
    Begum, Nelufa
    Byrnes, Catherine A.
    Cheney, Joyce
    Cooper, Peter J.
    Fantino, Emmanuelle
    Gailer, Nicholas
    Grimwood, Keith
    GutierrezCardenas, Diana
    Massie, John
    Robertson, Colin F.
    Sly, Peter D.
    Tiddens, Harm A. W. M.
    Wainwright, Claire E.
    Ware, Robert S.
    JOURNAL OF CYSTIC FIBROSIS, 2022, 21 (06) : 977 - 983
  • [23] Pretransplant HRCT Characteristics Are Associated with Worse Outcome of Lung Transplantation for Cystic Fibrosis Patients
    Belle-van Meerkerk, Gerdien
    de Jong, Pim A.
    de Valk, Harold W.
    Neefjes, Tim
    Pameijer, Frank A.
    Kwakkel-van Erp, Johanna M.
    van de Graaf, Ed A.
    PLOS ONE, 2015, 10 (12):
  • [24] Methicillin-resistant Staphylococcus aureus in patients with cystic fibrosis
    Giron, Rosa M.
    Buendia, Buenaventura
    Pinedo, Celia
    Casanova, Alvaro
    Hoyos, Nieves
    Ancochea, Julio
    ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA, 2009, 27 (02): : 85 - 88
  • [25] IRON SUPPLEMENTATION AND DEFECTIVE IRON HOMEOSTASIS ARE ASSOCIATED WITH WORSE LUNG FUNCTION IN CYSTIC FIBROSIS (CF)
    Smith, D. J.
    Badrick, A.
    Anderson, G. J.
    Bell, S. C.
    Reid, D. W.
    RESPIROLOGY, 2012, 17 : 41 - 41
  • [26] EPIDEMIOLOGY OF STAPHYLOCOCCUS-AUREUS IN PATIENTS WITH CYSTIC-FIBROSIS
    BRANGER, C
    FOURNIER, JM
    LOULERGUE, J
    BOUVET, A
    GOULLET, P
    BOUTONNIER, A
    DEGIALLULY, C
    COUETDIC, G
    CHOMARAT, M
    JAFFARBANJEE, MC
    MARIANI, P
    EPIDEMIOLOGY AND INFECTION, 1994, 112 (03): : 489 - 500
  • [27] Staphylococcus aureus with decreased susceptibility to glycopeptides in cystic fibrosis patients
    Filleron, Anne
    Chiron, Raphael
    Reverdy, Marie-Elisabeth
    Jean-Pierre, Helene
    Dumitrescu, Oana
    Aleyrangues, Linda
    Counil, Francois
    Jumas-Bilak, Estelle
    Marchandin, Helene
    JOURNAL OF CYSTIC FIBROSIS, 2011, 10 (05) : 377 - 382
  • [28] Extended Staphylococcus aureus persistence in cystic fibrosis is associated with bacterial adaptation
    Hirschhausen, Nina
    Block, Desiree
    Bianconi, Irene
    Bragonzi, Alessandra
    Birtel, Johannes
    Lee, Jean C.
    Duebbers, Angelika
    Kuester, Peter
    Kahl, Janina
    Peters, Georg
    Kahl, Barbara C.
    INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY, 2013, 303 (08) : 685 - 692
  • [29] Cystic fibrosis autoantibody signatures associate with Staphylococcus aureus lung infection or cystic fibrosis-related diabetes
    Yadav, Ruchi
    Li, Quan-Zhen
    Huang, Hanwen
    Bridges, S. Louis
    Kahlenberg, J. Michelle
    Stecenko, Arlene A.
    Rada, Balazs
    FRONTIERS IN IMMUNOLOGY, 2023, 14
  • [30] Factors Influencing Lung Function in Patients with Cystic Fibrosis in Western Romania
    Dediu, Mihaela
    Ciuca, Ioana Mihaiela
    Marc, Monica Steluta
    Boeriu, Estera
    Pop, Liviu Laurentiu
    JOURNAL OF MULTIDISCIPLINARY HEALTHCARE, 2021, 14 : 1423 - 1429