Changing Cities and Regions by the Knowledge and Innovation Based Economy

The attitudes of modern regional development policies in last few years have putted the emphasis to the strategic regional policy. Together with idea of knowledge based and innovative economy the public support was focused to the research and development and it's transfer to practical life. In the Czech Republic wide spectrum of R&D programs were established. There were built technological parks, entrepreneur and business incubators and other infrasfructure transferring knowledge from universities and R&D companies to praxis established. This paper presents results of almost 10 years of this attitude to regions in the Czech Republic. It summarizes impacts to the economic and social life of regions and to regional disparities.