Using personalized immune-humanized xenograft mouse models to predict immune checkpoint responses in malignant melanoma: potential and hurdles

被引：3
|
作者：
Helleday, T. [1 ,2 ]
机构：
[1] Univ Sheffield, Dept Oncol & Metab, Weston Pk Canc Ctr, Sheffield, S Yorkshire, England
[2] Karolinska Inst, Dept Oncol Pathol, Sci Life Lab, Stockholm, Sweden
来源：
ANNALS OF ONCOLOGY | 2020年 / 31卷 / 02期
基金：
瑞典研究理事会;
关键词：
PD-1; BLOCKADE;
D O I：
10.1016/j.annonc.2019.11.007
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
引用
收藏
页码：167 / 168
页数：2
相关论文
共 50 条
  • [21] A Potential Therapy Using Engineered Stem Cells Prevented Malignant Melanoma in Cellular and Xenograft Mouse Models
    Heo, Jae-Rim
    Hwang, Kyung-A
    Kim, Seung U.
    Choi, Kyung-Chul
    CANCER RESEARCH AND TREATMENT, 2019, 51 (02): : 797 - 811
  • [22] An Improved Patient-Derived Xenograft Humanized Mouse Model for Evaluation of Lung Cancer Immune Responses
    Meraz, Ismail M.
    Majidi, Mourad
    Meng, Feng
    Shao, RuPing
    Ha, Min Jin
    Neri, Shinya
    Fang, Bingliang
    Lin, Steven H.
    Tinkey, Peggy T.
    Shpall, Elizabeth J.
    Morris, Jeffrey
    Roth, Jack A.
    CANCER IMMUNOLOGY RESEARCH, 2019, 7 (08) : 1267 - 1279
  • [23] Rheumatic Toxicities of Immune Checkpoint Inhibitors Predict Favourable Tumour Responses in Patients with Advanced Melanoma
    Bruce, Alana
    Menzies, Alexander M.
    Long, Georgina V.
    Fernandes, Brian
    Joshua, Fredrick
    ARTHRITIS & RHEUMATOLOGY, 2022, 74 : 3319 - 3321
  • [24] Humanized knock-in mouse models for evaluating in vivo efficacy of immune-oncology drugs targeting stimulatory immune checkpoint molecules
    Gan, T.
    Xiang, J.
    Guo, C.
    Guo, Y.
    ANNALS OF ONCOLOGY, 2018, 29 : 420 - 420
  • [25] Humanized knock-in mouse models for evaluating in vivo efficacy of immune-oncology drugs targeting inhibitory immune checkpoint molecules
    Zhang, Baozhu
    Guo, Chaoshe
    Shen, Yuelei
    Guo, Yanan
    CANCER RESEARCH, 2018, 78 (13)
  • [26] Early C-reactive protein kinetics predict response to immune checkpoint inhibition in malignant melanoma
    Koett, J.
    Zimmermann, N.
    Zell, T.
    Heidrich, I.
    Geidel, G.
    Merkle, M.
    Hansen, I.
    Abeck, F.
    Ruenger, A.
    Reschke, R.
    Gebhardt, C.
    JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT, 2023, 21 : 49 - 49
  • [27] Advances in Humanized Mouse Models to Improve Understanding of HIV-1 Pathogenesis and Immune Responses
    Gillgrass, Amy
    Wessels, Jocelyn M.
    Yang, Jack X.
    Kaushic, Charu
    FRONTIERS IN IMMUNOLOGY, 2021, 11
  • [28] Functional characterization of neoantigens determining immune checkpoint blockade response in mouse models of human melanoma
    Guijarro, Eva Perez
    Day, Chi-Ping
    Ohler, Zoe W.
    El Meskini, Rajaa
    Yang, Howard
    Vodnala, Suman
    Graff-Cherry, Cari
    Chin, Sung
    Fon, Anyen
    Michael, Helen
    Lee, Maxwell
    Van Dyke, Terry
    Sharan, Shyam
    Merlino, Glenn
    CANCER RESEARCH, 2018, 78 (13)
  • [29] Novel Personalized Immune-Monitoring Assay for Predicting Operational Tolerance by Using Humanized Mouse Model
    Fukasaku, Y.
    Goto, R.
    Ganchiku, Y.
    Zaitsu, M.
    Watanabe, M.
    Kawamura, N.
    Koshizuka, Y.
    Yamashita, K.
    Shimamura, T.
    Taketomi, A.
    AMERICAN JOURNAL OF TRANSPLANTATION, 2017, 17 : 236 - 237
  • [30] Imaging Immune Cells Using Fc Domain Probes in Mouse Cancer Xenograft Models
    Bernhard, Wendy
    Barreto, Kris
    El-Sayed, Ayman
    DeCoteau, John
    Geyer, C. Ronald
    CANCERS, 2022, 14 (02)
12345