SPECTROPHOTOMETRIC DETERMINATION OF ACIDITY CONSTANTS OF SOME NOVEL METHOTREXATE-LIKE COMPOUNDS IN WATER AND ACETONITRILE-WATER BINARY MIXTURES

被引：0

作者：

Colak, Naki ^{[1
]}

Sanli, Senem ^{[1
]}

Sanli, Nurullah ^{[1
]}

机构：

[1] Hitit Univ, Dept Chem, Fac Arts & Sci, TR-19040 Corum, Turkey

来源：

REVIEWS IN ANALYTICAL CHEMISTRY | 2010年 / 29卷 / 3-4期

关键词：

Methotrexate; Acidity constants; Acetonitrile-water mixtures; Spectroscopic method; PK(A) VALUES; DISSOCIATION-CONSTANTS; PHARMACOLOGY;

D O I：

暂无

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The acidity constants of four novel methotrexate like compounds (NP-ALA; (N-[4-[[2-hydroxy - 1-naphtyl)methylene]amino]benzoyl-beta-alanin) TP-ALA; (N-[4-(2-thiophene-aldiminobenzoyl)-beta-alanin), SAL-ALA; N-[4-[[2-hydroxyphenyl)methylene]amino]benzoyl-beta-alanin], MeO-SAL-ALA; (N-[4-[[(2-hydroxy-4-methoxyphenyl)metylene]amino]benzoyl-beta-alanin)) have been determined in water and acetonitrile-water binary mixture (10%, and 20% (v/v)) by spectrophotometric method. The effect of the acetonitrile concentration on the ionization constant was also studied.

引用

页码：241 / 252

页数：12

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