Spectrophotometric Determination of Acidity Constants of Some Macrolides in Acetonitrile-Water Binary Mixtures

被引：0

作者：

Sanli, Senem ^{[1
]}

Sanli, Nurullah ^{[1
]}

Alsancak, Guleren ^{[2
]}

机构：

[1] Hitit Univ, Dept Chem, Fac Arts & Sci, TR-19040 Corum, Turkey

[2] Suleyman Demirel Univ, Fac Arts & Sci, Dept Chem, TR-32260 Isparta, Turkey

来源：

ACTA CHIMICA SLOVENICA | 2010年 / 57卷 / 04期

关键词：

Macrolides; Acidity constants; Acetonitrile-water mixtures; Spectroscopic method; PK(A) VALUES; DISSOCIATION-CONSTANTS; CAPILLARY-ELECTROPHORESIS; LIQUID-CHROMATOGRAPHY; DOSAGE FORMS; POTENTIOMETRY; ERYTHROMYCIN; PROGRAM; DRUGS; MEDIA;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The acidity constants of eight macrolides (erythromycin, roxithromycin. oleandomycin, azithromycin, josamycin, tylosin tartrate, tilmicosin and spiramycin) have been determined in acetonitrile-water binary mixtures (30%, 40% and 50% (v/v)) by spectrophotometric method. The pK(a)'s available in literature determined by various methods are compiled in comparison with the value of this work. These results are expected to essentially facilitate the research on occurrence, fate and effects, analysis method development, and control of antibiotics in various treatment occurrences.

引用

页码：980 / 987

页数：8

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