Hepatitis B Vaccination in HIV-Infected Youth: A Randomized Trial of Three Regimens

被引:41
|
作者
Flynn, Patricia M. [1 ,2 ,3 ]
Cunningham, Coleen K. [4 ]
Rudy, Bret [5 ]
Wilson, Craig M. [6 ]
Kapogiannis, Bill [7 ]
Worrell, Carol [7 ]
Bethel, James [8 ]
Monte, Dina [8 ]
Bojan, Kelly [9 ]
机构
[1] St Jude Childrens Res Hosp, Dept Infect Dis, Memphis, TN 38105 USA
[2] Univ Tennessee, Hlth Sci Ctr, Dept Pediat, Memphis, TN USA
[3] Univ Tennessee, Hlth Sci Ctr, Dept Prevent Med, Memphis, TN USA
[4] Duke Univ, Dept Pediat, Sch Med, Durham, NC 27706 USA
[5] NYU, Dept Pediat, Sch Med, New York, NY 10016 USA
[6] Univ Alabama Birmingham, Dept Epidemiol, Birmingham, AL USA
[7] Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Pediat Adolescent & Maternal AIDS Branch, NIH, Rockville, MD USA
[8] Westat Corp, Rockville, MD USA
[9] Core Ctr, Adolescent Div, Chicago, IL USA
基金
美国国家卫生研究院;
关键词
HIV; hepatitis B vaccination; adolescents; Engerix B; Twinrix; IMPAIRED RESPONSE; SEROLOGIC RESPONSE; ANTIBODY-RESPONSE; HOMOSEXUAL MEN; A VACCINE; CHILDREN; IMMUNIZATION; EFFICACY; INFANTS; IMMUNOGENICITY;
D O I
10.1097/QAI.0b013e318203e9f2
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Background: HIV-infected youth are at risk of hepatitis B infection and should be vaccinated. Previous reports suggest reduced response to standard hepatitis B vaccine regimens. Methods: HIV-infected youth, aged 12 to younger than 25 years, were randomly assigned to one of three treatment arms: Arm 1: Engerix B, 20 mg HBsAg; Arm 2: Engerix B (GlaxoSmithKline, Rixensart, Belgium), 40 mg; and Arm 3: Twinrix (GlaxoSmithKline, Rixensart, Belgium), 20 mg HBsAg combined with 720 ELU hepatitis A antigen. Vaccines were administered at Weeks 0, 4, and 24. Results: Characteristics of evaluable patients (n = 336) at entry were similar in the study arms. At enrollment, median CD4(+) T-cell count was 460 cells/mm(3) (interquartile range, 305-668); 13% were less than 200 cells/mm(3). Among Engerix B, 20-mg recipients, 60.4% responded to vaccine (HBsAb 10 IU/mL or greater at Week 28). Improved vaccine response was seen in recipients of Engerix B, 40 mg (73.2% versus Arm 1, P = 0.04) and Twinrix (75.4% versus Arm 1, P = 0.02). In multivariate analysis, only baseline CD4(+) T-cell count and study arm were independent predictors of vaccine response. Conclusions: In HIV-infected youth, a three-dose vaccination regimen with Engerix B, 40 mg, or Twinrix and higher baseline CD4(+) T-cell counts were independently associated with improved vaccine response.
引用
收藏
页码:325 / 332
页数:8
相关论文
共 50 条
  • [41] Vaccination in HIV-Infected Adults
    Crum-Cianflone, Nancy F.
    Wallace, Mark R.
    AIDS PATIENT CARE AND STDS, 2014, 28 (08) : 397 - 410
  • [42] Vaccination in HIV-infected patients
    Sybil A. Tasker
    Mark R. Wallace
    Current Infectious Disease Reports, 2000, 2 (3) : 247 - 256
  • [43] Hepatitis B virus infection in HIV-infected persons
    Chloe L. Thio
    Current Hepatitis Reports, 2004, 3 (3) : 91 - 97
  • [44] Chronic hepatitis B and C in HIV-infected patients
    Opravil, M
    Hunziker, R
    Luthy, R
    Grob, PJ
    DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT, 1998, 123 (24) : 753 - 760
  • [45] Retrobulbar optic neuritis after Hepatitis A vaccination in a HIV-infected patient
    E H Z Huang
    S A Lim
    P L Lim
    Y S Leo
    Eye, 2009, 23 : 2267 - 2271
  • [46] Retrobulbar optic neuritis after Hepatitis A vaccination in a HIV-infected patient
    Huang, E. H. Z.
    Lim, S. A.
    Lim, P. L.
    Leo, Y. S.
    EYE, 2009, 23 (12) : 2267 - 2271
  • [47] Comparison of Immunogenicity and Safety of Four Doses and Four Double Doses vs. Standard Doses of Hepatitis B Vaccination in HIV-Infected Adults: A Randomized, Controlled Trial
    Chaiklang, Kanokporn
    Wipasa, Jiraprapa
    Chaiwarith, Romanee
    Praparattanapan, Jutarat
    Supparatpinyo, Khuanchai
    PLOS ONE, 2013, 8 (11):
  • [48] Investigation of Hepatitis B and Hepatitis C Seroprevalence in HIV-infected Patients
    Inci, Ayse
    KLIMIK JOURNAL, 2018, 31 (01) : 34 - 36
  • [49] High rates of serological response to a modified hepatitis B vaccination schedule in HIV-infected adults subjects
    Potsch, D. V.
    Oliveira, M. L. A.
    Ginuino, C.
    Miguel, J. C.
    Oliveira, S. A. N.
    Silva, E. F.
    Moreira, R. B.
    Cruz, G. V. M.
    Oliveira, A. L. V. S. M.
    Camacho, L. A. B.
    Barroso, P. F.
    VACCINE, 2010, 28 (06) : 1447 - 1450
  • [50] Occult hepatitis B virus infection and S gene escape mutants in HIV-infected patients after hepatitis B virus vaccination
    Aghakhani, Arezoo
    Mohraz, Minoo
    Aghasadeghi, Mohammad Reza
    Banifazl, Mohammad
    Vahabpour, Rouhollah
    Karami, Afsaneh
    Foroughi, Maryam
    Ramezani, Amitis
    INTERNATIONAL JOURNAL OF STD & AIDS, 2016, 27 (11) : 967 - 972