Sarcoeleganolides C-G, Five New Cembranes from the South China Sea Soft Coral Sarcophyton elegans

被引：7

作者：

Wang, Cili ^{[1
,2
]}

Zhang, Jiarui ^{[1
,2
]}

Shi, Xing ^{[1
,2
]}

Li, Kai ^{[1
,2
]}

Li, Fengling ^{[3
]}

Tang, Xuli ^{[4
]}

Li, Guoqiang ^{[1
,2
]}

Li, Pinglin ^{[1
,2
]}

机构：

[1] Ocean Univ China, Sch Med & Pharm, Key Lab Marine Drugs, Chinese Minist Educ, Qingdao 266003, Peoples R China

[2] Natl Lab Marine Sci & Technol, Lab Marine Drugs & Biol Prod, Qingdao 266235, Peoples R China

[3] Qilu Univ Technol, Biol Inst, Shandong Acad Sci, Jinan 250103, Peoples R China

[4] Ocean Univ China, Coll Chem & Chem Engn, Qingdao 266100, Peoples R China

来源：

MARINE DRUGS | 2022年 / 20卷 / 09期

基金：

中国国家自然科学基金;

关键词：

Sarcophyton elegans; sarcoeleganolides C-G; cembranes; anti-inflammation activity; CYTOTOXIC CEMBRANOLIDES; DITERPENES; STEREOCHEMISTRY; PRODUCTS;

D O I：

10.3390/md20090574

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Five new cembranes, named sarcoeleganolides C-G (1-5), along with three known analogs (6-8) were isolated from soft coral Sarcophyton elegans collected from the Yagong Island, South China Sea. Their structures and absolute configurations were determined by extensive spectroscopic analysis, QM-NMR, and TDDFT-ECD calculations. In addition, compound 3 exhibited better anti-inflammation activity compared to the indomethacin as a positive control in zebrafish at 20 mu M.

引用

页数：10

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