Sarcoeleganolides C-G, Five New Cembranes from the South China Sea Soft Coral Sarcophyton elegans

被引：7
|
作者：
Wang, Cili [1 ,2 ]
Zhang, Jiarui [1 ,2 ]
Shi, Xing [1 ,2 ]
Li, Kai [1 ,2 ]
Li, Fengling [3 ]
Tang, Xuli [4 ]
Li, Guoqiang [1 ,2 ]
Li, Pinglin [1 ,2 ]
机构：
[1] Ocean Univ China, Sch Med & Pharm, Key Lab Marine Drugs, Chinese Minist Educ, Qingdao 266003, Peoples R China
[2] Natl Lab Marine Sci & Technol, Lab Marine Drugs & Biol Prod, Qingdao 266235, Peoples R China
[3] Qilu Univ Technol, Biol Inst, Shandong Acad Sci, Jinan 250103, Peoples R China
[4] Ocean Univ China, Coll Chem & Chem Engn, Qingdao 266100, Peoples R China
来源：
MARINE DRUGS | 2022年 / 20卷 / 09期
基金：
中国国家自然科学基金;
关键词：
Sarcophyton elegans; sarcoeleganolides C-G; cembranes; anti-inflammation activity; CYTOTOXIC CEMBRANOLIDES; DITERPENES; STEREOCHEMISTRY; PRODUCTS;
D O I：
10.3390/md20090574
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Five new cembranes, named sarcoeleganolides C-G (1-5), along with three known analogs (6-8) were isolated from soft coral Sarcophyton elegans collected from the Yagong Island, South China Sea. Their structures and absolute configurations were determined by extensive spectroscopic analysis, QM-NMR, and TDDFT-ECD calculations. In addition, compound 3 exhibited better anti-inflammation activity compared to the indomethacin as a positive control in zebrafish at 20 mu M.
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页数：10
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