BACH2 regulates CD8+ T cell differentiation by controlling access of AP-1 factors to enhancers

被引：203

作者：

Roychoudhuri, Rahul ^{[1
,2
]}

Clever, David ^{[1
,3
]}

Li, Peng ^{[4
,5
]}

Wakabayashi, Yoshiyuki ^{[6
]}

Quinn, Kylie M. ^{[7
]}

Klebanoff, Christopher A. ^{[1
]}

Ji, Yun ^{[1
]}

Sukumar, Madhusudhanan ^{[1
]}

Eil, Robert L. ^{[1
]}

Yu, Zhiya ^{[1
]}

Spolski, Rosanne ^{[4
,5
]}

Palmer, Douglas C. ^{[1
]}

Pan, Jenny H. ^{[1
]}

Patel, Shashank J. ^{[1
]}

Macallan, Derek C. ^{[8
]}

Fabozzi, Giulia ^{[1
]}

Shih, Han-Yu ^{[9
]}

Kanno, Yuka ^{[9
]}

Muto, Akihiko ^{[10
,11
]}

Zhu, Jun ^{[6
]}

Gattinoni, Luca ^{[1
]}

O'Shea, John J. ^{[9
]}

Okkenhaug, Klaus ^{[2
]}

Igarashi, Kazuhiko ^{[10
,11
]}

Leonard, Warren J. ^{[4
,5
]}

Restifo, Nicholas P. ^{[1
,12
]}

机构：

[1] NCI, NIH, Bethesda, MD 20892 USA

[2] Babraham Inst, Lab Lymphocyte Signalling & Dev, Cambridge, England

[3] Ohio State Univ, Coll Med, Med Scientist Training Program, Columbus, OH 43210 USA

[4] NHLBI, Lab Mol Immunol, NIH, Bldg 10, Bethesda, MD 20892 USA

[5] NHLBI, Ctr Immunol, NIH, Bldg 10, Bethesda, MD 20892 USA

[6] NHLBI, Syst Biol Ctr, NIH, Bldg 10, Bethesda, MD 20892 USA

[7] NIAID, Vaccine Res Ctr, NIH, Bethesda, MD USA

[8] St Georges Univ London, Inst Infect & Immun, London, England

[9] NIAMSD, Mol Immunol & Inflammat Branch, NIH, Bethesda, MD 20892 USA

[10] Tohoku Univ, Dept Biochem, Grad Sch Med, Sendai, Miyagi 980, Japan

[11] Japan Agcy Med Res & Dev, AMED CREST, Tokyo, Japan

[12] Georgetown Univ, Med Ctr, Grad Program Microbiol & Immunol, Washington, DC 20007 USA

来源：

NATURE IMMUNOLOGY | 2016年 / 17卷 / 07期

基金：

英国惠康基金; 英国生物技术与生命科学研究理事会;

关键词：

TRANSCRIPTION FACTORS; EXPRESSION ANALYSIS; MEMORY PHENOTYPE; EFFECTOR; GENE; REPRESSES; LYMPHOCYTES; ACTIVATION; GENERATION; PROTEINS;

D O I：

10.1038/ni.3441

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

T cell antigen receptor (TCR) signaling drives distinct responses depending on the differentiation state and context of CD8(+) T cells. We hypothesized that access of signal-dependent transcription factors (TFs) to enhancers is dynamically regulated to shape transcriptional responses to TCR signaling. We found that the TF BACH2 restrains terminal differentiation to enable generation of long-lived memory cells and protective immunity after viral infection. BACH2 was recruited to enhancers, where it limited expression of TCR-driven genes by attenuating the availability of activator protein-1 (AP-1) sites to Jun family signal-dependent TFs. In naive cells, this prevented TCR-driven induction of genes associated with terminal differentiation. Upon effector differentiation, reduced expression of BACH2 and its phosphorylation enabled unrestrained induction of TCR-driven effector programs.

引用

页码：851 / +

页数：12

共 50 条

[41] Differentiation and Persistence of Memory CD8+ T Cells Depend on T Cell Factor 1
Zhou, Xinyuan
Yu, Shuyang
Zhao, Dong-Mei
Harty, John T.
Badovinac, Vladimir P.
Xue, Hai-Hui
IMMUNITY, 2010, 33 (02) : 229 - 240
[42] MicroRNA-181a regulates IFN-γ expression in effector CD8+ T cell differentiation
Tiago Amado
Ana Amorim
Francisco J. Enguita
Paula V. Romero
Daniel Inácio
Marta Pires de Miranda
Samantha J. Winter
J. Pedro Simas
Andreas Krueger
Nina Schmolka
Bruno Silva-Santos
Anita Q. Gomes
Journal of Molecular Medicine, 2020, 98 : 309 - 320
[43] STAT3 regulates CD8+ T cell differentiation and functions in cancer and acute infection
Sun, Qinli
Zhao, Xiaohong
Li, Ruifeng
Liu, Dingfeng
Pan, Birui
Xie, Bowen
Chi, Xinxin
Cai, Dongli
Wei, Peng
Xu, Wei
Wei, Kun
Zhao, Zixuan
Fu, Yujie
Ni, Ling
Dong, Chen
JOURNAL OF EXPERIMENTAL MEDICINE, 2023, 220 (04):
[44] MicroRNA-181a regulates IFN-γ expression in effector CD8+ T cell differentiation
Amado, Tiago
Amorim, Ana
Enguita, Francisco J.
Romero, Paula, V
Inacio, Daniel
de Miranda, Marta Pires
Winter, Samantha J.
Pedro Simas, J.
Krueger, Andreas
Schmolka, Nina
Silva-Santos, Bruno
Gomes, Anita Q.
JOURNAL OF MOLECULAR MEDICINE-JMM, 2020, 98 (02): : 309 - 320
[45] Bach2 represses the AP-1-driven induction of interleukin-2 gene transcription in CD4+ T cells
Jang, Eunkyeong
Lee, Hye Rim
Lee, Geon Hee
Oh, Ah-Reum
Cha, Ji-Young
Igarashi, Kazuhiko
Youn, Jeehee
BMB REPORTS, 2017, 50 (09) : 472 - 477
[46] mTORC1 and mTORC2 selectively regulate CD8+ T cell differentiation
Pollizzi, Kristen N.
Patel, Chirag H.
Sun, Im-Hong
Oh, Min-Hee
Waickman, Adam T.
Wen, Jiayu
Delgoffe, Greg M.
Powell, Jonathan D.
JOURNAL OF CLINICAL INVESTIGATION, 2015, 125 (05): : 2090 - 2108
[47] Erratum: Epigenetic landscapes reveal transcription factors that regulate CD8+ T cell differentiation
Bingfei Yu
Kai Zhang
J Justin Milner
Clara Toma
Runqiang Chen
James P Scott-Browne
Renata M Pereira
Shane Crotty
John T Chang
Matthew E Pipkin
Wei Wang
Ananda W Goldrath
Nature Immunology, 2017, 18 (6) : 705 - 705
[48] One naive T cell, multiple fates in CD8+ T cell differentiation
Gerlach, Carmen
van Heijst, Jeroen W. J.
Swart, Erwin
Sie, Daoud
Armstrong, Nicola
Kerkhoven, Ron M.
Zehn, Dietmar
Bevan, Michael J.
Schepers, Koen
Schumacher, Ton N. M.
JOURNAL OF EXPERIMENTAL MEDICINE, 2010, 207 (06): : 1235 - 1246
[49] BACH2 enforces the transcriptional and epigenetic programs of stem-like CD8+ T cells (vol 22, pg 370, 2021)
Yao, Chen
Lou, Guohua
Sun, Hong-Wei
Zhu, Ziang
Sun, Yi
Chen, Zeyu
Chauss, Daniel
Moseman, E. Ashley
Cheng, Jun
D'Antonio, Marc A.
Shi, Wangke
Shi, Junwei
Kometani, Kohei
Kurosaki, Tomohiro
Wherry, E. John
Afzali, Behdad
Gattinoni, Luca
Zhu, Yuwen
McGavern, Dorian B.
O'Shea, John J.
Schwartzberg, Pamela L.
Wu, Tuoqi
NATURE IMMUNOLOGY, 2021, 22 (04) : 530 - 530
[50] Granzyme B Regulates Antiviral CD8+ T Cell Responses
Salti, Suzan M.
Hammelev, Erin M.
Grewal, Jenny L.
Reddy, Sreelatha T.
Zemple, Sarah J.
Grossman, William J.
Grayson, Mitchell H.
Verbsky, James W.
JOURNAL OF IMMUNOLOGY, 2011, 187 (12): : 6301 - 6309

← 1 2 3 4 5 →