Dialdehyde-β-cyclodextrin-crosslinked carboxymethyl chitosan hydrogel for drug release

A simple method was proposed for preparing the dialdehyde-beta-cyclodextrin (DA-beta-CD) cross-linked carboxymethyl chitosan (CMCS) hydrogels for drug delivery. DA-beta-CD was yielded from the sodium periodate oxidation of beta-CD. Phenolphthalein (PhP) was adopted as a model drug to study the drug loading and releasing properties of the obtained hydrogels. The results show that the ability of the hydrogel to load drug is affected by the aldehyde content of DA-beta-CD. The inclusion constant of DA-beta-CD toward PhP is lower than that of the original beta-CD and decreased with the rising of the aldehyde content. An increased cross-linking degree between DA-beta-CD and CMCS slows the PhP release to some extent. In comparison with glyoxal/CMCS, DA-beta-CD/CMCS presents better PhP release properties. Only 19.2 % of PhP loaded in glyoxal/CMCS was released within 24 h. Half of PhP loaded in DA-beta-CD/CMCS was released in 2 h and about 90 % was released within 12h.