Extracellular matrix players in metastatic niches

被引：70
|
作者：
Oskarsson, Thordur [3 ]
Massague, Joan [1 ,2 ]
机构：
[1] Mem Sloan Kettering Canc Ctr, Cell Biol & Genet Program, New York, NY 10021 USA
[2] Mem Sloan Kettering Canc Ctr, Howard Hughes Med Inst, New York, NY 10021 USA
[3] Heidelberg Inst Stem Cell Technol & Expt Med HI S, Heidelberg, Germany
来源：
EMBO JOURNAL | 2012年 / 31卷 / 02期
关键词：
BREAST-CANCER CELLS; TENASCIN-C; LUNGS;
D O I：
10.1038/emboj.2011.469
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Metastatic niches support the survival and fitness of disseminated tumour cells (DTCs) in otherwise inhospitable tissue environments. The components of metastatic niches have remained a matter of conjecture, but recent reports, including one in a current issue of Nature, point at the extracellular matrix (ECM) proteins periostin and tenascin C (TNC) as key metastatic niche molecules. By enhancing Wnt and Notch signalling in cancer cells, these proteins provide physical as well as signalling support for metastasis-initiating cells. These findings underscore the importance of the ECM environment in cancer and provide potential drug targets against metastasis.
引用
收藏
页码：254 / 256
页数：3
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