Bioactivity and biodegradability of high temperature sintered 58S ceramics

Bioactive glasses are often considered in bone tissue engineering applications where mechanical strength is essential. As such, bioactive glass scaffolds are often sintered to improve mechanical strength. However, sintering can lead to crystallization, which reduces bioactivity and biodegradability. It has generally been considered that amorphous biomaterials exhibit better bioactivity. However, the in-vitro bioactivity and biodegradability of the sintered 58S made from initial amorphous powder and partially crystalline powder with the same chemical compositions (60SiO(2)-36CaO-4P(2)O(5) (mol%)) have not been compared before. In this study, 58S bioactive glass (fully amorphous) and glass-ceramic (partially crystallized) powders were synthesized using the sol-gel process, followed by heat-treating at 600 degrees C for 3 h (calcination). The powders were mixed with carboxymethyl cellulose solution as a binder, shaped in a cylindrical mold, dried, and then sintered at 1100 degrees C for 5 h. The in-vitro bioactivity and biodegradability of the sintered samples were assessed in simulated body fluid (SBF) for times up to 28 days. The specimens were investigated before and after immersion in SBF using X-ray powder diffraction (XRD), Scanning Electron Microscopy (SEM), and Fourier transform infrared spectroscopy (FT-IR). The In-vitro bioactivity and biodegradability rate of the sintered 58S produced from the glass ceramic powder were higher than that from fully amorphous powder. This study shows that the initial structure after calcination is important and affects the subsequent crystallization during sintering. Therefore, crystallinity and formation of hydroxyapatite after calcination are important controlling mechanisms that can increase the bioactivity and biodegradability rate of sintered 58S.