BK virus-associated nephropathy in a patient with AIDS

被引：13
|
作者：
Sukov, William R. [1 ]
Lewin, Matthew [1 ]
Sethi, Sanjeev [1 ]
Rakowski, Thomas A. [2 ]
Lager, Donna J. [1 ]
机构：
[1] Mayo Clin, Dept Lab Med & Pathol, Rochester, MN 55905 USA
[2] Virginia Hosp Ctr, Arlington, VA USA
来源：
AMERICAN JOURNAL OF KIDNEY DISEASES | 2008年 / 51卷 / 04期
关键词：
BK virus; human immunodeficiency virus (HIV); acquired immunodeficiency syndrome (AIDS); interstitial nephritis;
D O I：
10.1053/j.ajkd.2007.11.030
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
The BK virus is a ubiquitous member of the group of human polyoma viruses that commonly is reactivated in the setting of immunosuppression related to renal transplantation, which results in tubulointerstitial nephritis and allograft dysfunction. BK virus-associated nephropathy occurring in association with human immunodeficiency virus infection and acquired immunodeficiency syndrome (AIDS) was reported only rarely. We describe the case of a 43-year-old man with AIDS presenting with nonoliguric renal failure. The renal biopsy specimen showed tubulointerstitial nephritis and renal tubular cell changes consistent with BK viral inclusions. Results of in situ hybridization for BK viral DNA were positive and showed tubular cell intranuclear inclusions. To our knowledge, this represents the third case of AIDS-associated BK virus-associated nephropathy diagnosed by means of biopsy. Am J Kidney Dis 51:e1 5-e18. (c) 2008 by the National Kidney Foundation, Inc.
引用
收藏
页码：E15 / E18
页数：4
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