Adenylyl Cyclase-Associated Protein 1: Structure, Regulation, and Participation in Cellular Processes

被引：20

作者：

Kakurina, G. V. ^{[1
]}

Kolegova, E. S. ^{[1
]}

Kondakova, I. V. ^{[1
]}

机构：

[1] Russian Acad Sci, Tomsk Natl Res Med Ctr, Canc Res Inst, Tomsk 634050, Russia

来源：

BIOCHEMISTRY-MOSCOW | 2018年 / 83卷 / 01期

基金：

俄罗斯基础研究基金会;

关键词：

adenylyl cyclase-associated protein 1; actin-binding proteins; cell migration; prokaryotes; eukaryotes; pathological processes; SACCHAROMYCES-CEREVISIAE; ACTIN CYTOSKELETON; SRV2/CAP COMPLEX; TYROSINE KINASE; CAP1; GENE; COFILIN; EXPRESSION; MIGRATION; HOMOLOG;

D O I：

10.1134/S0006297918010066

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This review summarizes information available to date about the structural organization, regulation of functional activity of adenylyl cyclase-associated protein 1 (CAP1), and its participation in cellular processes. Numerous data are generalized on the role of CAP1 in the regulation of actin cytoskeleton and its interactions with many actin-binding proteins. Attention is drawn to the similarity of the structure of CAP1 and its contribution to the remodeling of actin filaments in prokaryotes and eukaryotes, as well as to the difference in the interaction of CAP1 with adenylyl cyclase in these cells. In addition, we discuss the participation of CAP1 in various pathological processes.

引用

页码：45 / 53

页数：9

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