ANALYSIS OF THE ASSOCIATION BETWEEN SH2B1 CHR16.28884655 AND TYPE 2 DIABETES

被引：0
|
作者：
Liu, Jingjin [1 ]
Cao, Renjun [2 ]
Li, Dewei [1 ]
Miao, Fang [1 ]
Yang, Ping An [1 ]
He, Hui [1 ]
Yu, Han [1 ]
Zhang, Xiang [1 ]
Qin, Jie [1 ]
Yang, Yanlan [1 ]
机构：
[1] Shanxi Prov Peoples Hosp, Endocrinol, Taiyuan, Peoples R China
[2] Affiliated Changzhi Med Coll, Endocrinol, Heji Hosp, Changzhi, Peoples R China
来源：
CLINICAL AND INVESTIGATIVE MEDICINE | 2022年 / 45卷 / 04期
关键词：
VARIANTS; OBESITY;
D O I：
10.25011/cim.v45i4.39273
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Purpose: To determine correlation between genetic susceptibility of type 2 diabetes mellitus (T2DM) and Src homology 2 B adapter protein 1 (SH2B1) gene polymorphism in a diabetic population. Methods: A total of 111 T2DM patients (DM group) and 34 healthy controls (NC group) from Shanxi Provincial People's Hospital were included in this study. Exon 9 of the SH2B1 gene was detected using the Sanger sequencing method, and the relationship between SH2B1 gene polymorphism and diabetes was analyzed.Results: Comparison of the data between the two groups showed that the values of TG, the updated HOMA of insulin resistance (HOMA2-IR), weight, body mass index, waist circumference, fasting blood glucose and fasting insulin levels of the DM group were higher than those of the NC group (P < 0.05). The HOMA2 insulin sensitivity (%S) of the DM group was lower than that of the NC group (P < 0.05). Sequencing analysis revealed that the following five single nucleotide polymorphisms in exon 9 of SH2B1 may be related to T2DM: rs181578610, rs550079240, chr16.28884655, chr16.28884659 and chr16.28884831. Among them, chr16.28884655 was found to be significantly related to diabetes; this site, located on the NM_015503 exon, was related to TG, LDL-C and waist circumference. Conclusion: The SH2B1 gene locus chr16.28884655 was found to be significantly related to genetic susceptibility to T2DM.
引用
收藏
页码：E33 / E38
页数：6
相关论文
共 50 条
  • [41] Association of genetic variants of MAOA and SH2B1 with bone mineral density in community-dwelling Japanese women
    Yamada, Yoshiji
    Ando, Fujiko
    Shimokata, Hiroshi
    MOLECULAR MEDICINE REPORTS, 2008, 1 (02) : 269 - 274
  • [42] Common variants near BDNF and SH2B1 show nominal evidence of association with snacking behavior in European populations
    Sébastien Robiou-du-Pont
    Loïc Yengo
    Emmanuel Vaillant
    Stéphane Lobbens
    Emmanuelle Durand
    Fritz Horber
    Olivier Lantieri
    Michel Marre
    Beverley Balkau
    Philippe Froguel
    David Meyre
    Journal of Molecular Medicine, 2013, 91 : 1109 - 1115
  • [43] Common variants near BDNF and SH2B1 show nominal evidence of association with snacking behavior in European populations
    Robiou-du-Pont, Sebastien
    Yengo, Loic
    Vaillant, Emmanuel
    Lobbens, Stéphane
    Durand, Emmanuelle
    Horber, Fritz
    Lantieri, Olivier
    Marre, Michel
    Balkau, Beverley
    Froguel, Philippe
    Meyre, David
    JOURNAL OF MOLECULAR MEDICINE-JMM, 2013, 91 (09): : 1109 - 1115
  • [44] The SH2B1 obesity locus and abnormal glucose homeostasis: Lack of evidence for association from a meta-analysis in individuals of European ancestry
    Prudente, S.
    Copetti, M.
    Morini, E.
    Mendonca, C.
    Andreozzi, F.
    Chandalia, M.
    Baratta, R.
    Pellegrini, F.
    Mercuri, L.
    Bailetti, D.
    Abate, N.
    Frittitta, L.
    Sesti, G.
    Florez, J. C.
    Doria, A.
    Trischitta, V.
    NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES, 2013, 23 (11) : 1043 - 1049
  • [45] SH2B1 is Involved in the Accumulation of Amyloid-β42 in Alzheimer's Disease
    Shen, Yijun
    Xia, Yiling
    Meng, Shiquan
    Lim, Nastasia K. H.
    Wang, Wenan
    Huang, Fude
    JOURNAL OF ALZHEIMERS DISEASE, 2017, 55 (02) : 835 - 847
  • [46] The nonlinear association between apolipoprotein B to apolipoprotein A1 ratio and type 2 diabetes
    Mao, Yong
    Xu, Yang
    Lu, Leihong
    MEDICINE, 2017, 96 (01)
  • [47] Association between chronic hepatitis B and diabetes complications: Analysis of 0.5 million Chinese with type 2 diabetes
    Lau, E. S. H.
    Wu, H.
    Yang, A.
    Zhang, X.
    Chow, E.
    Kong, A.
    Ma, R.
    Chan, J.
    Luk, A.
    DIABETES RESEARCH AND CLINICAL PRACTICE, 2022, 186
  • [48] Genetic Obesity in Children: Overview of Possible Diagnoses with a Focus on SH2B1 Deletion
    Giannopoulou, Eleni Z.
    Zorn, Stefanie
    Schirmer, Melanie
    Herrmann, Gloria
    Heger, Sabine
    Reinehr, Thomas
    Denzer, Christian
    Rabenstein, Hannah
    Hillmer, Morten
    Sowada, Nadine
    Siebert, Reiner
    von Schnurbein, Julia
    Wabitsch, Martin
    HORMONE RESEARCH IN PAEDIATRICS, 2022, 95 (02): : 137 - 148
  • [49] Analysis of overlapping genetic association in type 1 and type 2 diabetes
    Jamie R. J. Inshaw
    Carlo Sidore
    Francesco Cucca
    M. Irina Stefana
    Daniel J. M. Crouch
    Mark I. McCarthy
    Anubha Mahajan
    John A. Todd
    Diabetologia, 2021, 64 : 1342 - 1347
  • [50] Analysis of overlapping genetic association in type 1 and type 2 diabetes
    Inshaw, Jamie R. J.
    Sidore, Carlo
    Cucca, Francesco
    Stefana, M. Irina
    Crouch, Daniel J. M.
    McCarthy, Mark I.
    Mahajan, Anubha
    Todd, John A.
    DIABETOLOGIA, 2021, 64 (06) : 1342 - 1347
12345