Effect of an exclusive human milk diet on feeding tolerance in preterm infants

被引:2
|
作者
El-Fadeel, Hiba [1 ]
Velumula, Pradeep [1 ]
Lulic-Botica, Mirjana [2 ]
Natarajan, Girija [3 ]
Thomas, Ronald [3 ]
Botica, Gabriella [4 ]
Bajaj, Monika [3 ]
机构
[1] Childrens Hosp Michigan, Dept Pediat, Detroit, MI 48201 USA
[2] Wayne State Univ, Dept Pharm, Detroit, MI 48201 USA
[3] Cent Michigan Univ, Dept Pediat, Detroit, MI 48201 USA
[4] Wayne State Univ, Detroit, MI 48201 USA
关键词
NECROTIZING ENTEROCOLITIS; INTESTINAL FAILURE; BREAST-MILK; MORTALITY; GROWTH;
D O I
10.1038/s41372-022-01348-y
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
OBJECTIVE: To compare the time to full enteral feeds in preterm infants fed exclusive human milk (EHM) - mother's own milk (MOM) fortified with human milk-based fortifier (HMBF), to those who received partial human milk (PHM) - MOM fortified with bovine milk-based fortifier (BMBF), and exclusive formula. STUDY DESIGN: A single-center retrospective study of infants with birth weight <1250 g from 2013 to 2018. Data on feeding, growth and other short-term neonatal morbidities were collected. RESULTS: On regression analysis, time to full enteral feeds was significantly higher in PHM compared to EHM group (beta-coefficient 4.14, 95% CI 0.00-8.29) and formula-fed group compared to EHM (beta-coefficient 4.3, 95% CI 0.32-8.20). No significant differences in growth velocity, length of stay and other morbidities were found between the groups. CONCLUSION: Infants in EHM had better feeding tolerance and reached their enteral feed goals sooner compared to PHM and formula-fed groups.
引用
收藏
页码:1070 / 1075
页数:6
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