Synthetic studies of pseurotin A: preparation of an advanced lactam aldehyde intermediate

被引：10

作者：

Mitchell, JM ^{[1
]}

Finney, NS ^{[1
]}

机构：

[1] Univ Calif San Diego, Dept Biochem & Chem, La Jolla, CA 92093 USA

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2005年 / 3卷 / 23期

关键词：

D O I：

10.1039/b512701g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient synthesis of the lactam core of pseurotin A has been accomplished. Key features of this synthesis include a tandem oxidation-cyclization to form the lactam from an acetylenic amide precursor. Although coupling of a lactam aldehyde with an appropriate side chain was not effective, it is anticipated that incorporating a partial side chain at an earlier stage should permit completion of the total synthesis of pseurotin A.

引用

页码：4274 / 4281

页数：8

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