Innate inflammatory responses to the Gram-positive bacterium Lactococcus lactis

被引：31
|
作者：
Yam, Karen K. [1 ]
Pouliot, Philippe [1 ,2 ]
N'diaye, Marie M. [1 ]
Fournier, Sylvie [1 ]
Olivier, Martin [1 ,2 ]
Cousineau, Benoit [1 ]
机构：
[1] McGill Univ, Dept Microbiol & Immunol, Montreal, PQ H3A 2B4, Canada
[2] McGill Univ, Ctr Hlth, Ctr Study Host Resistance, Res Inst, Montreal, PQ H3A 2B4, Canada
来源：
VACCINE | 2008年 / 26卷 / 22期
基金：
加拿大健康研究院;
关键词：
Lactococcus lactis; adjuvant; chemokines;
D O I：
10.1016/j.vaccine.2008.03.024
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Lactococcus lactis is a non-pathogenic and non-colonizing Gram-positive bacterium commonly used in the dairy industry. To support the potential. applications of this bacterium, such as use as an oral live vaccine, it is of interest to investigate the adjuvant properties of L. lactis. We compared the proinflammatory effects of L. lactis with two non-pathogenic Gram-negative bacteria: Escherichia coli and Salmonella typhi, a widely studied live vaccine. The gene expression profiles of chemokines induced by the three bacteria were examined in macrophages in vitro and in cells recruited into murine air-pouches in vivo. In addition, we studied the effect of co-incubating bacteria with dendritic cells (DCs) generated from mice bone marrow. We demonstrate that L. lactis exhibits proinflammatory effects, which indicates a capacity for adjuvanticity by this bacterium.(C) 2008 Etsevier Ltd. ALL rights reserved.
引用
收藏
页码：2689 / 2699
页数：11
相关论文
共 50 条
  • [41] Subtilisin QK-2: secretory expression in Lactococcus lactis and surface display onto gram-positive enhancer matrix (GEM) particles
    Mao, Ruifeng
    Zhou, Kangping
    Han, Zhenwei
    Wang, Yefu
    [J]. MICROBIAL CELL FACTORIES, 2016, 15
  • [42] GRAM-POSITIVE
    AINLEYWALKER, EW
    [J]. LANCET, 1946, 250 (JAN19): : 110 - 110
  • [43] Expression of the Streptococcus agalactiae virulence-associated protease CspA in a soluble, active form utilizing the Gram-positive host, Lactococcus lactis
    Shelver, Daniel
    Brayan, Joshua D.
    [J]. JOURNAL OF BIOTECHNOLOGY, 2008, 136 (3-4) : 129 - 134
  • [44] Antimicrobial Activity of Lactococcus lactis subsp. lactis Isolated from a Stranded Cuvier's Beaked Whale (Ziphius cavirostris) against Gram-Positive and -Negative Bacteria
    Suzuki, Akihiko
    Suzuki, Miwa
    [J]. MICROORGANISMS, 2021, 9 (02) : 1 - 14
  • [45] Lactococcus lactis, a bacterium with probiotic functions and pathogenicity
    Fan Wu
    Xinmei Xie
    Tao Du
    Xiaodan Jiang
    Wei Miao
    Tiancheng Wang
    [J]. World Journal of Microbiology and Biotechnology, 2023, 39
  • [46] Lactococcus lactis, a bacterium with probiotic functions and pathogenicity
    Wu, Fan
    Xie, Xinmei
    Du, Tao
    Jiang, Xiaodan
    Miao, Wei
    Wang, Tiancheng
    [J]. WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY, 2023, 39 (12):
  • [47] Respiration capacity of the fermenting bacterium Lactococcus lactis and its positive effects on growth and survival
    Duwat, P
    Sourice, S
    Cesselin, B
    Lamberet, G
    Vido, K
    Gaudu, P
    Le Loir, Y
    Violet, F
    Loubière, P
    Gruss, A
    [J]. JOURNAL OF BACTERIOLOGY, 2001, 183 (15) : 4509 - 4516
  • [48] Electroactivity of the Gram-positive bacterium Paenibacillus dendritiformis MA-72
    Hubenova, Yolina
    Hubenova, Eleonora
    Mitov, Mario
    [J]. BIOELECTROCHEMISTRY, 2020, 136 (136)
  • [49] Effects of ultraviolet radiation on the Gram-positive marine bacterium Microbacterium maritypicum
    Williams, Patrick D.
    Eichstadt, Shaundra L.
    Kokjohn, Tyler A.
    Martin, Eugene L.
    [J]. CURRENT MICROBIOLOGY, 2007, 55 (01) : 1 - 7
  • [50] Regulation mechanism of lysC riboswitch in gram-positive bacterium Bacillus subtilis
    Sun, Yuying
    Wang, Yanli
    Tan, Zhi-Jie
    Zhang, Wenbing
    [J]. JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2020, 38 (09): : 2784 - 2791
12345