Polarization diversity of human CD4+ stem cell memory T cells

被引：29

作者：

Takeshita, Masaru ^{[1
]}

Suzuki, Katsuya ^{[1
]}

Kassai, Yoshiaki ^{[2
]}

Takiguchi, Maiko ^{[2
]}

Nakayama, Yusuke ^{[3
]}

Otomo, Yuki ^{[1
]}

Morita, Rimpei ^{[4
]}

Miyazaki, Takahiro ^{[2
,4
]}

Yoshimura, Akihiko ^{[4
]}

Takeuchi, Tsutonnu ^{[1
]}

机构：

[1] Keio Univ, Sch Med, Div Rheumatol,Dept Internal Med, Shinjuku Ku, Tokyo 1608582, Japan

[2] Takeda Pharmaceut Co Ltd, Div Pharmaceut Res, Inflammat Drug Discovery Unit, Fujisawa, Kanagawa 2518555, Japan

[3] Takeda Pharmaceut Co Ltd, Div Pharmaceut Res, Integrated Technol Res Labs, Fujisawa, Kanagawa 2518555, Japan

[4] Keio Univ, Sch Med, Dept Microbiol & Immunol, Shinjuku Ku, Tokyo 1608582, Japan

来源：

CLINICAL IMMUNOLOGY | 2015年 / 159卷 / 01期

关键词：

Helper T cell; Stem cell memory T; Th17; precursor; TGF-BETA; HELPER-CELLS; T(H)17 CELLS; EFFECTOR; DIFFERENTIATION; LINEAGE; CYTOKINE; SPECIFICITY; GENERATION; PHENOTYPE;

D O I：

10.1016/j.clim.2015.04.010

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

T cells are considered to develop through three stages, from naive T (Tn) into central memory T (Tcm) and finally into effector memory T (Tem). Among the subsets of Tn, stem cell memory T (Tscm) were recently found to be the least developed memory subset. While this subset was revealed to possess self-reproducibility and multipotentiality, little is known about the relationship between development and polarity. We conducted transcriptome analysis of human CD4(+) T subsets and found that Tscm was a clearly distinct subset, located between Tn and Tcm. Surface antigen analysis and differentiation assay showed that the flexibility of polarity and the cytokine production progressively changed as the differentiation of CD4(+) T cells advanced. Interestingly, we found that most cells of the CD45RO(-)CCR7(+)CCR6(+) subset, hitherto considered the naive precursor of Th17, were in fact Tscm. These findings may advance our understanding of the highly heterogeneous human helper T cells. (C) 2015 Elsevier Inc. All rights reserved.

引用

页码：107 / 117

页数：11

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