Inhibition of angiogenesis by extracellular protein kinase A

被引：10
|
作者：
Szkudlarek, Maria [1 ]
Bosio, Rual M. [2 ]
Wu, Qiong [1 ]
Chin, Khew-Voon [1 ,3 ,4 ]
机构：
[1] Univ Toledo, Dept Med, Coll Med, Toledo, OH 43614 USA
[2] Univ Toledo, Dept Surg, Coll Med, Toledo, OH 43614 USA
[3] Univ Toledo, Dept Biochem & Canc Biol, Coll Med, Toledo, OH 43614 USA
[4] Univ Toledo, Ctr Diabet & Endocrine Res, Coll Med, Toledo, OH 43614 USA
来源：
CANCER LETTERS | 2009年 / 283卷 / 01期
关键词：
ECPKA; Angiogenesis; Extracellular; PKA; Chorioallantoic; CANCER BIOMARKER; CYCLIC-AMP; CAMP; LOCALIZATION; EXPRESSION;
D O I：
10.1016/j.canlet.2009.03.027
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The cyclic-AMP dependent protein kinase (PKA) signaling pathway regulates cell growth, development, metabolism, and gene expression. Peripheral blood of cancer patients but not normal individuals, shows increased catalytic subunit levels of PKA (PKAc). We showed here that this extracellular form of PKAc (ECPKA) from conditioned media of cultured cancer cells as well as purified PKAc inhibit angiogenesis, using the in utero chicken embryo chorioallantoic membrane assay. Inhibition of angiogenesis is partially reversed by PKI, a peptide inhibitor of PKA, thus suggesting an anti-angiogenic role for ECPKA. The significance of ECPKA in cancer is discussed. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：68 / 73
页数：6
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