Human Neutralizing Monoclonal Antibody Inhibition of Middle East Respiratory Syndrome Coronavirus Replication in the Common Marmoset

被引：61
|
作者：
Chen, Zhe [1 ,2 ]
Bao, Linlin [3 ,4 ]
Chen, Cong [1 ,2 ]
Zou, Tingting [5 ]
Xue, Ying [1 ,2 ]
Li, Fengdi [3 ,4 ]
Lv, Qi [3 ,4 ]
Gu, Songzhi [3 ,4 ]
Gao, Xiaopan [1 ,2 ]
Cui, Sheng [1 ,2 ]
Wang, Jianmin [1 ,2 ]
Qin, Chuan [3 ,4 ]
Jin, Qi [1 ,2 ,6 ]
机构：
[1] Chinese Acad Med Sci, Inst Pathogen Biol, MOH Key Lab Syst Biol Pathogens, Beijing, Peoples R China
[2] Peking Union Med Coll, Beijing, Peoples R China
[3] Chinese Acad Med Sci, Inst Lab Anim Sci, Beijing, Peoples R China
[4] Peking Union Med Coll, Key Lab Human Dis Comparat Med, Minist Hlth, Beijing Key Lab Anim Models Emerging & Remerging, Beijing, Peoples R China
[5] Huazhong Agr Univ, Coll Life Sci & Technol, Wuhan, Peoples R China
[6] Collaborat Innovat Ctr Diag & Treatment Infect Di, Hangzhou, Zhejiang, Peoples R China
来源：
JOURNAL OF INFECTIOUS DISEASES | 2017年 / 215卷 / 12期
基金：
美国国家科学基金会;
关键词：
human monoclonal antibody; MERS-CoV; common marmoset; RECEPTOR-BINDING DOMAIN; MERS-COV; DROMEDARY CAMELS; SPIKE PROTEIN; INFECTION; BAT; TRANSMISSION; EFFICACY; THERAPY; HKU4;
D O I：
10.1093/infdis/jix209
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Middle East respiratory syndrome coronavirus (MERS-CoV) infection in humans is highly lethal, with a fatality rate of 35%. New prophylactic and therapeutic strategies to combat human infections are urgently needed. We isolated a fully human neutralizing antibody, MCA1, from a human survivor. The antibody recognizes the receptor-binding domain of MERS-CoV S glycoprotein and interferes with the interaction between viral S and the human cellular receptor human dipeptidyl peptidase 4 (DPP4). To our knowledge, this study is the first to report a human neutralizing monoclonal antibody that completely inhibits MERS-CoV replication in common marmosets. Monotherapy with MCA1 represents a potential alternative treatment for human infections with MERS-CoV worthy of evaluation in clinical settings.
引用
收藏
页码：1807 / 1815
页数：9
相关论文
共 50 条
  • [31] Middle East Respiratory Syndrome Coronavirus in Children
    Das, Karuna M.
    Lee, Edward Y.
    [J]. INDIAN PEDIATRICS, 2016, 53 (08) : 752 - 752
  • [32] Middle East respiratory syndrome coronavirus conference
    McConnell, John
    [J]. LANCET INFECTIOUS DISEASES, 2013, 13 (08): : 661 - 661
  • [33] Middle East Respiratory Syndrome (MERS) Coronavirus
    McFee, R. B.
    [J]. DM DISEASE-A-MONTH, 2020, 66 (09):
  • [34] Novel Middle East respiratory syndrome coronavirus
    Wiwanitkit, Viroj
    [J]. JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION, 2014, 113 (01) : 65 - 65
  • [35] The influence of interferon-lambda on restricting Middle East Respiratory Syndrome Coronavirus replication in the respiratory epithelium
    Jeon, Yung Jin
    Gil, Chan Hee
    Jo, Ara
    Won, Jina
    Kim, Sujin
    Kim, Hyun Jik
    [J]. ANTIVIRAL RESEARCH, 2020, 180
  • [36] Development of a rapid diagnostic kit for antigen and antibody of Middle East respiratory syndrome coronavirus
    Lee, Eun-Young
    Ko, Hae Li
    Jung, Seo-Yeon
    Nam, Jae-Hwan
    [J]. JOURNAL OF IMMUNOLOGY, 2017, 198 (01):
  • [37] Longevity of Middle East Respiratory Syndrome Coronavirus Antibody Responses in Humans, Saudi Arabia
    Alshukairi, Abeer N.
    Zhao, Jincun
    Al-Mozaini, Maha A.
    Wang, Yanqun
    Dada, Ashraf
    Baharoon, Salim A.
    Alfaraj, Sara
    Ahmed, Waleed A.
    Enani, Mushira A.
    Elzein, Fatehi E.
    Eltayeb, Nazik
    Layqah, Laila
    El-Saed, Aiman
    Bahaudden, Husam A.
    Haseeb, Abdul
    El-Kafrawy, Sherif A.
    Hassan, Ahmed M.
    Siddiq, Najlaa A.
    Alsharif, Ibtihaj
    Qushmaq, Isamel
    Azhar, Esam, I
    Perlman, Stanley
    Memish, Ziad A.
    [J]. EMERGING INFECTIOUS DISEASES, 2021, 27 (05) : 1472 - 1476
  • [38] Assessing the Detection of Middle East Respiratory Syndrome Coronavirus IgG in Suspected and Proven Cases of Middle East Respiratory Syndrome Coronavirus Infection
    Alhetheel, Abdulkarim
    Altalhi, Haifa
    Albarrag, Ahmed
    Shakoor, Zahid
    Mohamed, Deqa
    El-Hazmi, Malak
    Somily, Ali
    Barry, Mazin
    Bakhrebah, Muhammed
    Nassar, Majed
    [J]. VIRAL IMMUNOLOGY, 2017, 30 (09) : 649 - 653
  • [39] Coronaviruses: severe acute respiratory syndrome coronavirus and Middle East respiratory syndrome coronavirus in travelers
    Al-Tawfiq, Jaffar A.
    Zumla, Alimuddin
    Memish, Ziad A.
    [J]. CURRENT OPINION IN INFECTIOUS DISEASES, 2014, 27 (05) : 411 - 417
  • [40] Proficiency testing for the detection of Middle East respiratory syndrome coronavirus demonstrates global capacity to detect Middle East respiratory syndrome coronavirus
    Theis, Torsten
    Lau, Katherine A.
    Gray, Joanna L.
    Oxenford, Christopher J.
    Walker, Gregory J.
    Rawlinson, William D.
    [J]. JOURNAL OF MEDICAL VIROLOGY, 2018, 90 (12) : 1827 - 1833
12345