Human Neutralizing Monoclonal Antibody Inhibition of Middle East Respiratory Syndrome Coronavirus Replication in the Common Marmoset

被引：61

作者：

Chen, Zhe ^{[1
,2
]}

Bao, Linlin ^{[3
,4
]}

Chen, Cong ^{[1
,2
]}

Zou, Tingting ^{[5
]}

Xue, Ying ^{[1
,2
]}

Li, Fengdi ^{[3
,4
]}

Lv, Qi ^{[3
,4
]}

Gu, Songzhi ^{[3
,4
]}

Gao, Xiaopan ^{[1
,2
]}

Cui, Sheng ^{[1
,2
]}

Wang, Jianmin ^{[1
,2
]}

Qin, Chuan ^{[3
,4
]}

Jin, Qi ^{[1
,2
,6
]}

机构：

[1] Chinese Acad Med Sci, Inst Pathogen Biol, MOH Key Lab Syst Biol Pathogens, Beijing, Peoples R China

[2] Peking Union Med Coll, Beijing, Peoples R China

[3] Chinese Acad Med Sci, Inst Lab Anim Sci, Beijing, Peoples R China

[4] Peking Union Med Coll, Key Lab Human Dis Comparat Med, Minist Hlth, Beijing Key Lab Anim Models Emerging & Remerging, Beijing, Peoples R China

[5] Huazhong Agr Univ, Coll Life Sci & Technol, Wuhan, Peoples R China

[6] Collaborat Innovat Ctr Diag & Treatment Infect Di, Hangzhou, Zhejiang, Peoples R China

来源：

JOURNAL OF INFECTIOUS DISEASES | 2017年 / 215卷 / 12期

基金：

美国国家科学基金会;

关键词：

human monoclonal antibody; MERS-CoV; common marmoset; RECEPTOR-BINDING DOMAIN; MERS-COV; DROMEDARY CAMELS; SPIKE PROTEIN; INFECTION; BAT; TRANSMISSION; EFFICACY; THERAPY; HKU4;

D O I：

10.1093/infdis/jix209

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Middle East respiratory syndrome coronavirus (MERS-CoV) infection in humans is highly lethal, with a fatality rate of 35%. New prophylactic and therapeutic strategies to combat human infections are urgently needed. We isolated a fully human neutralizing antibody, MCA1, from a human survivor. The antibody recognizes the receptor-binding domain of MERS-CoV S glycoprotein and interferes with the interaction between viral S and the human cellular receptor human dipeptidyl peptidase 4 (DPP4). To our knowledge, this study is the first to report a human neutralizing monoclonal antibody that completely inhibits MERS-CoV replication in common marmosets. Monotherapy with MCA1 represents a potential alternative treatment for human infections with MERS-CoV worthy of evaluation in clinical settings.

引用

页码：1807 / 1815

页数：9

共 50 条

[1] Human Monoclonal Antibody Cocktail for the Treatment or Prophylaxis of Middle East Respiratory Syndrome Coronavirus
Sivapalasingam, Sumathi
Saviolakis, George A.
Kulcsar, Kirsten
Nakamura, Aya
Conrad, Thomas
Hassanein, Mohamed
Sumner, Giane
Elango, Chinnasamy
Kamal, Mohamed A.
Eng, Simon
Kyratsous, Christos A.
Musser, Bret J.
Frieman, Matthew
Kantrowitz, Joel
Weinreich, David M.
Yancopoulos, George
Stahl, Neil
Lipsich, Leah
[J]. JOURNAL OF INFECTIOUS DISEASES, 2021, 225 (10): : 1765 - 1772
[2] Inhibition of Middle East Respiratory Syndrome Coronavirus Infection by Anti-CD26 Monoclonal Antibody
Ohnuma, Kei
Haagmans, Bart L.
Hatano, Ryo
Raj, V. Stalin
Mou, Huihui
Iwata, Satoshi
Dang, Nam H.
Bosch, Berend Jan
Morimoto, Chikao
[J]. JOURNAL OF VIROLOGY, 2013, 87 (24) : 13892 - 13899
[3] Ultrapotent Human Neutralizing Antibody Repertoires Against Middle East Respiratory Syndrome Coronavirus From a Recovered Patient
Niu, Peihua
Zhang, Senyan
Zhou, Panpan
Huang, Baoying
Deng, Yao
Qin, Kun
Wang, Pengfei
Wang, Wenling
Wang, Xinquan
Zhou, Jianfang
Zhang, Linqi
Tan, Wenjie
[J]. JOURNAL OF INFECTIOUS DISEASES, 2018, 218 (08): : 1249 - 1260
[4] Neutralizing Monoclonal Antibodies as Promising Therapeutics against Middle East Respiratory Syndrome Coronavirus Infection
Han, Hui-Ju
Liu, Jian-Wei
Yu, Hao
Yu, Xue-Jie
[J]. VIRUSES-BASEL, 2018, 10 (12):
[5] Comparative pathology of rhesus macaque and common marmoset animal models with Middle East respiratory syndrome coronavirus
Yu, Pin
Xu, Yanfeng
Deng, Wei
Bao, Linlin
Huang, Lan
Xu, Yuhuan
Yao, Yanfeng
Qin, Chuan
[J]. PLOS ONE, 2017, 12 (02):
[6] Towards the prophylactic and therapeutic use of human neutralizing monoclonal antibodies for Middle East respiratory syndrome coronavirus (MERS-CoV)
Sakamoto, Seiichi
Tanaka, Hiroyuki
Morimoto, Satoshi
[J]. ANNALS OF TRANSLATIONAL MEDICINE, 2015, 3 (03)
[7] A novel human coronavirus: Middle East respiratory syndrome human coronavirus
HeYuan Geng
WenJie Tan
[J]. Science China Life Sciences, 2013, 56 : 683 - 687
[8] A novel human coronavirus: Middle East respiratory syndrome human coronavirus
Geng HeYuan
Tan WenJie
[J]. SCIENCE CHINA-LIFE SCIENCES, 2013, 56 (08) : 683 - 687
[9] A novel human coronavirus:Middle East respiratory syndrome human coronavirus
GENG HeYuan
TAN WenJie
[J]. Science China Life Sciences, 2013, (08) : 683 - 687
[10] A novel human coronavirus:Middle East respiratory syndrome human coronavirus
GENG HeYuan
TAN WenJie
[J]. Science China(Life Sciences)., 2013, 56 (08) - 687

← 1 2 3 4 5 →