Cystic fibrosis in ukraine: Age, origin and tracing of the Delta F508 mutation

被引：0

作者：

Livshits, LA ^{[1
]}

Kravchenko, SA ^{[1
]}

机构：

[1] NATL ACAD SCI UKRAINE,INST MOL BIOL & GENET,LAB MOL MOL DIAGNOST HEREDITARY DIS,KIEV,UKRAINE

来源：

GENE GEOGRAPHY | 1996年 / 10卷 / 03期

关键词：

D O I：

暂无

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Seven already known CF mutations were searched in 170 unrelated cystic fibrosis patients from different regions of Ukraine. Their frequencies in this sample were: Delta F508 - 50%, 1677delTA - 0.3% (10th exon), R553X - 0.6%, G551D - 0.3% (11th exon), R334W - 0.6% (7th exon). 1154insTC (7th exon) and S549I (11th exon) were not found. Heterozygotes for Delta F508 were searched in 865 healthy volunteers from different Ukranian regions. Their frequencies ranged from 1:28 to 1:70. We report here unpublished population data from Ukraine in order to discuss the origin, evolution and dispersion of chromosomes bearing the Delta F508 mutation. Selection in terms of heterozygote advantage is also discussed.

引用

页码：219 / 227

页数：9

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