Pathogenic role and therapeutic potential of fibro-adipogenic progenitors in muscle disease

被引：9
|
作者：
Hogarth, Marshall W. [1 ]
Uapinyoying, Prech [1 ,2 ]
Mazala, Davi A. G. [1 ,3 ]
Jaiswal, Jyoti K. [1 ,4 ]
机构：
[1] Childrens Natl Hosp, Ctr Genet Med Res, Washington, DC USA
[2] NINDS, Neuromuscular & Neurogenet Disorders Childhood Se, NIH, Bethesda, MD 20892 USA
[3] Towson Univ, Dept Knesiol, Coll Hall Profess, Towson, MD USA
[4] George Washington Univ, Sch Med & Hlth Sci, Dept Genom & Precis Med, Washington, DC 20052 USA
来源：
TRENDS IN MOLECULAR MEDICINE | 2022年 / 28卷 / 01期
关键词：
REGENERATION;
D O I：
10.1016/j.molmed.2021.10.003
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Aside from myofibers, numerous mononucleated cells reside in the skeletal muscle. These include the mesenchymal cells called fibro-adipogenic progenitors (FAPs), that support muscle development and regeneration in adult muscles. Recent evidence shows that defects in FAP function contributes to chronic muscle diseases and targeting FAPs offers avenues for treating these diseases.
引用
收藏
页码：8 / 11
页数：4
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