Peculiarities of bone marrow hemopoiesis in early aging OXYS rats

被引：3
|
作者：
Orlovskaya, I. A. [1 ]
Toporkova, L. B.
Feofanova, N. A.
Kolosova, N. G.
机构：
[1] Russian Acad Med Sci, Inst Clin Immunol, Siberian Div, Moscow 109801, Russia
[2] Russian Acad Sci, Siberian Div, Inst Cytol & Genet, Novosibirsk, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2007年 / 144卷 / 01期
基金：
俄罗斯基础研究基金会;
关键词：
hemopoietic precursors; hemopoietic stem cell; early aging; OXYS rats;
D O I：
10.1007/s10517-007-0262-0
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Colony-forming activity of bone marrow cells in 3-and 12-month-old Wistar rats does not differ by the number of early and erythroid precursors and by the formation of granulocyte-macrophage colonies. In senescence-accelerated OXYS rats, the number of early and erythroid precursors significantly increases by the age of 12 months and surpasses the corresponding values in Wistar rats. The number of granulocyte-macrophage colonies in OXYS rats does not change with age, but the numbers of these colonies formed at the age of 3 and 12 months in these animals are higher than in Wistar rats. As a result, the total number of hemopoietic colonies in 12-month-old OXYS rats 2-fold surpassed that in 12-month-old Wistar rats. Activation of granulopoiesis and increased numbers of early and erythroid precursors indicate deep changes in the functional status of the hemopoietic stem cell in 1-year-old OXYS rats in the direction characteristic of aging animals.
引用
收藏
页码：86 / 88
页数：3
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