Blood Coagulation Parameters and Platelet Indices Change in Normal and Preeclamptic Pregnant Women, 2022

Background: The hypercoagulable state of preeclamptic women can cause multiple organ dysfunction, systematic metabolic disorders, and even endanger the lives of the mother and fetus. As a result, the onset and clinical severity of preeclampsia are well predicted by the coagulative and fibrinolytic status.Aim: The current study aimed to explore the variation in laboratory markers of the coagulation-fibrinolytic system and evaluate their potential value in predicting the severity of preeclampsia for early intervention.Patients and methods: A case-control study was conducted in Salahadeen General Hospital /Gynecology and Obstetrics department during the period from the 1st of January to the 30th of June 2022. A convenient sampling method was adopted to enrol 100 pregnant women in the current study and included two groups: The case group (consisted of 50 pregnant women who presented with preeclampsia) and the control group (consisted of 50 healthy pregnant women who were matched with the case group regarding the age. A P-value < 0.05 considered statistically significantResults: According to the results of the current study, the means of prothrombin time, activated partial thromboplastin time, and International Normalized Ratio were significantly higher in the case group than in the control group. The platelet count and plateletcrit were significantly lower in the case group compared to the control group (P-values were 0.001 and 0.002, respectively).In conclusion, the platelet indices can also be used in the prediction and early diagnosis of preeclampsia and as markers for the severity of preeclampsia. The coagulation parameters including prothrombin time, activated partial thromboplastin time, and International Normalized Ratio were significantly elevated in pregnant women with preeclampsia and can be used in the diagnosis, assessment of the severity, and follow-up.