Synthesis and Cytotoxic Activity of Arylsubstituted Tetrazolocyclanopyrimidines

被引：0
|
作者：
Vasil'kova, N. O. [1 ]
Ivonin, M. A. [1 ]
Burygin, G. L. [2 ]
Prilepskii, A. Yu. [2 ]
Kriven'ko, A. P. [1 ]
机构：
[1] NG Chernyshevskii Saratov State Natl Res Univ, Saratov, Russia
[2] Inst Plant & Microbial Biochem & Physiol, Saratov, Russia
来源：
PHARMACEUTICAL CHEMISTRY JOURNAL | 2017年 / 51卷 / 09期
关键词：
tetrazoloquinazolines; tetrazolocyclanopyrimidines; isomers; NMR spectra; cytotoxicity; SPEV-2; cells;
D O I：
10.1007/s11094-017-1687-z
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of arylsubstituted tetrazolocyclanodihydropyrimidines was prepared and their cytotoxic actions on SPEV-2 cells were studied. The activity of these substances was found to depend on the nature and position of the substitution groups in the benzene ring and the size of the alicycle. The most active compounds were o-chloro(methyl)phenyltetrazolohexahydroquinazolines.
引用
收藏
页码：756 / 759
页数：4
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