Dengue virus cross-reactive hemagglutination inhibition antibody responses in patients with primary dengue virus infection

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作者
Anantapreecha, Surapee
A-nuegoonpipat, Atchareeya
Prakrong, Songthum
Chanama, Sumalee
Sa-ngasang, Areerat
Sawanpanyalert, Pathom
Kurane, Ichiro
机构
[1] Minist Publ Hlth, Dept Med Sci, Natl Inst Hlth, Muang 11000, Nonthaburi, Thailand
[2] Natl Inst Infect Dis, Dept Virol 1, Tokyo 1628640, Japan
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R51 [传染病];
学科分类号
100401 ;
摘要
Acute and convalescent plasma samples were obtained from 101 confirmed primary dengue cases: 48 cases infected with dengue virus type 1, 10 cases with type 2, 42 cases with type 3 and one case with type 4. The hemagglutination inhibition (HI) titers of individual samples were at levels similar to each of the 4 dengue viruses at both the acute and convalescent stages, irrespective of the dengue virus that infected the patients. The results indicate that HI antibodies to dengue viruses are cross-reactive. When an HI test is used as a diagnostic test for dengue virus infection, the cross-reactive nature needs to be considered when interpreting the results.
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页码:267 / 270
页数:4
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