Genetic studies of GRN and IFT74 in arnyotrophic lateral sclerosis

被引：7

作者：

Xiao, Shangxi ^{[1
]}

Sato, Christine ^{[1
]}

Kawarai, Toshitaka ^{[1
]}

Goodall, Emily F. ^{[2
]}

Pall, Hardev S. ^{[2
,3
]}

Zinman, Lorne H. ^{[4
]}

Robertson, Janice ^{[1
]}

Morrison, Karen ^{[2
,3
]}

Rogaeva, Ekaterina ^{[1
,5
]}

机构：

[1] Univ Toronto, Ctr Res Neurodegenerat Dis, Toronto, ON M5S 3H2, Canada

[2] Univ Birmingham, Dept Clin Neurosci, Inst Biomed Res, Birmingham B15 2TT, W Midlands, England

[3] Univ Birmingham, Queen Elizabeth Hosp, NHS Fdn Trust, Birmingham B15 2TT, W Midlands, England

[4] Univ Toronto, Sunnybrook Hlth Sci Ctr, Toronto, ON, Canada

[5] Univ Toronto, Dept Med, Div Neurol, Toronto, ON M5S 1A1, Canada

来源：

NEUROBIOLOGY OF AGING | 2008年 / 29卷 / 08期

基金：

加拿大健康研究院;

关键词：

amyotrophic lateral sclerosis; single nucleotide polymorphism; progranulin; risk factor;

D O I：

10.1016/j.neurobiolaging.2007.02.022

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

There is increasing evidence of a clinical, neuropathological and genetic overlap between frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). We conducted a case-control study using a UK dataset to test the hypothesis that polymorphisms in two FTD-related genes (GRN and FT74) are associated with increased susceptibility to ALS. We evaluated the majority of known genetic variability in IFT74 and GRN. The results revealed that the common variations in IFT74 and GRN neither constitute strong ALS risk factors nor modify the age-at-onset. However, the possibility of a modest risk effect remains to be assessed in large datasets. (c) 2007 Elsevier Inc. All rights reserved.

引用

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页码：1279 / 1282

页数：4

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