Association of SCARB1 Variants With Subclinical Atherosclerosis and Incident Cardiovascular Disease The Multi-Ethnic Study of Atherosclerosis

被引：37
|
作者：
Manichaikul, Ani [2 ,3 ]
Naj, Adam C. [4 ]
Herrington, David [5 ]
Post, Wendy [6 ]
Rich, Stephen S. [2 ]
Rodriguez, Annabelle [1 ]
机构：
[1] Johns Hopkins Univ, Sch Med, Div Endocrinol, Johns Hopkins Bayview Med Ctr,Dept Med, Baltimore, MD 21224 USA
[2] Univ Virginia, Ctr Publ Hlth Genom, Div Biostat & Epidemiol, Charlottesville, VA USA
[3] Univ Virginia, Dept Publ Hlth Sci, Div Biostat & Epidemiol, Charlottesville, VA USA
[4] Univ Miami, Miller Sch Med, John P Hussman Inst Human Genom, Dr John T Macdonald Fdn Dept Human Genet, Miami, FL 33136 USA
[5] Wake Forest Univ, Dept Internal Med, Sch Med, Winston Salem, NC 27109 USA
[6] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA
来源：
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY | 2012年 / 32卷 / 08期
基金：
美国国家卫生研究院;
关键词：
cardiovascular disease; genetics; genomics; lipids; B TYPE-I; HIGH-DENSITY-LIPOPROTEIN; GENOME-WIDE ASSOCIATION; HDL CHOLESTEROL LEVELS; CORONARY-HEART-DISEASE; SCAVENGER RECEPTOR; SR-BI; MYOCARDIAL-INFARCTION; GENE LOCUS; POLYMORPHISMS;
D O I：
10.1161/ATVBAHA.112.249714
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Objective-We previously reported a statistically significant association of SCARB1 intronic single nucleotide polymorphism (SNP) rs10846744 with common carotid intimal-medial artery thickness in each of the 4 Multi-Ethnic Study of Atherosclerosis racial/ethnic groups (white, Chinese, black, and Hispanic). Methods and Results-Using an expanded sample of 7936 Multi-Ethnic Study of Atherosclerosis participants, phenotyped for measures of subclinical atherosclerosis, incident myocardial infarction, and cardiovascular disease, and genotyped through the SNP Health Association Resource project, we have now examined the genetic association of these phenotypes with 126 genotyped and imputed SCARB1 SNPs. We also performed stratified analyses to examine whether SCARB1 SNP effects differed by sex. Our analysis of the full Multi-Ethnic Study of Atherosclerosis cohort provides strong evidence for the association of rs10846744 with common carotid intimal-medial thickness (P=1.04E-4 in combined analysis of all 4 Multi-Ethnic Study of Atherosclerosis racial/ethnic groups). In sex-stratified analysis, we observed statistically significant association of rs10846744 with incident cardiovascular disease events in males (P=0.01). Examining analytical results from the Myocardial Infarction Genetics Consortium for replication, we observed further support for the association of rs10846744 with myocardial infarction. Conclusion-The SCARB1 SNP, rs10846744, exerts a major effect on subclinical atherosclerosis and incident cardiovascular disease in humans. (Arterioscler Thromb Vasc Biol. 2012;32:1991-1999.)
引用
收藏
页码：1991 / U583
页数：15
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