Antiviral Efficacy of Pralatrexate against SARS-CoV-2

被引：9
|
作者：
Bae, Joon-Yong [1 ]
Lee, Gee Eun [1 ]
Park, Heedo [1 ]
Cho, Juyoung [1 ]
Kim, Jeonghun [1 ]
Lee, Jungmin [1 ]
Kim, Kisoon [1 ]
Kim, Jin Il [1 ,2 ]
Park, Man-Seong [1 ,2 ]
机构：
[1] Korea Univ, Inst Viral Dis, Dept Microbiol, Coll Med, Seoul 02841, South Korea
[2] Korea Univ, Biosafety Ctr, Coll Med, Seoul 02841, South Korea
来源：
BIOMOLECULES & THERAPEUTICS | 2021年 / 29卷 / 03期
基金：
新加坡国家研究基金会;
关键词：
Antiviral; COVID-19; Drug repurposing; SARS-CoV-2;
D O I：
10.4062/biomolther.2021.032
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Novel coronavirus (SARS-CoV-2) has caused more than 100 million confirmed cases of human infectious disease (COVID-19) since December 2019 to paralyze our global community. However, only limited access has been allowed to COVID-19 vaccines and antiviral treatment options. Here, we report the efficacy of the anticancer drug pralatrexate against SARS-CoV-2. In Vero and human lung epithelial Calu-3 cells, pralatrexate reduced viral RNA copies of SARS-CoV-2 without detectable cytotoxicity, and viral replication was successfully inhibited in a dose-dependent manner. In a time-to-addition assay, pralatrexate treatment at almost half a day after infection also exhibited inhibitory effects on the replication of SARS-CoV-2 in Calu-3 cells. Taken together, these results suggest the potential of pralatrexate as a drug repurposing COVID-19 remedy.
引用
收藏
页码：268 / 272
页数：5
相关论文
共 50 条
  • [31] In vitro antiviral effect of silver nanoparticles against SARS-CoV-2
    Florez-Alvarez, Lizdany
    Hernandez, Juan C.
    Zapata, Wildeman
    Charry-Zuluaga, Jose Ivan
    Jaramillo, Jose R.
    Taborda, Natalia A.
    Gonzalez, Juan D.
    Martinez, Larry L.
    Yassin, Lina M.
    IATREIA, 2023, 36 (01) : 5 - 15
  • [32] Compelling Evidence for the Activity of Antiviral Peptides against SARS-CoV-2
    Tonk, Miray
    Ruzek, Daniel
    Vilcinskas, Andreas
    VIRUSES-BASEL, 2021, 13 (05):
  • [33] Boron enhances the antiviral activity of the curcumin against SARS-CoV-2
    Scorei, Ion Romulus
    Bita, Andrei
    Mogosanu, George Dan
    ROMANIAN JOURNAL OF MORPHOLOGY AND EMBRYOLOGY, 2020, 61 (03): : 967 - 970
  • [34] Antiviral Activity of Zinc Oxide Nanoparticles against SARS-CoV-2
    Wolfgruber, Stella
    Rieger, Julia
    Cardozo, Olavo
    Punz, Benjamin
    Himly, Martin
    Stingl, Andreas
    Farias, Patricia M. A.
    Abuja, Peter M.
    Zatloukal, Kurt
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (09)
  • [35] New Routes to Antiviral Molnupiravir against SARS-CoV-2 Infection
    Liu Zheng
    Yang Jing
    Liu Fengwu
    CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2022, 42 (09) : 2988 - 2993
  • [36] In Vitro Antiviral Activity of Nordihydroguaiaretic Acid against SARS-CoV-2
    Villalobos-Sanchez, Erendira
    Garcia-Ruiz, Daniel
    Camacho-Villegas, Tanya A.
    Canales-Aguirre, Alejandro A.
    Gutierrez-Ortega, Abel
    Munoz-Medina, Jose E.
    Elizondo-Quiroga, Darwin E.
    VIRUSES-BASEL, 2023, 15 (05):
  • [37] In silico evidence of beauvericin antiviral activity against SARS-CoV-2
    Al Khoury, Charbel
    Bashir, Zainab
    Tokajian, Sima
    Nemer, Nabil
    Merhi, Georgi
    Nemer, Georges
    COMPUTERS IN BIOLOGY AND MEDICINE, 2022, 141
  • [38] An in vitro antiviral activity of iodine complexes against SARS-CoV-2
    Imran Altaf
    Muhammad Faisal Nadeem
    Nadir Hussain
    Muhammad Nawaz
    Sohail Raza
    Muhammad Abu bakr Shabbir
    Muhammad Adnan Ashraf
    Muhammad Asad Ali
    Sohail Hassan
    Muhammad Waqar Aziz
    Nazish Matti
    Muhammad Ashraf
    Ihsan Ulla
    Sehar Fazal
    Saira Rafique
    Adnan Mehmood
    Nageen Sardar
    Muhammad Tahir Khan
    Hafiz Muhammad Moavia Atique
    Sohaib Ashraf
    Zarfishan Tahir
    Nadia Mukhtar
    Tahir Yaqub
    Archives of Microbiology, 2021, 203 : 4743 - 4749
  • [39] Amphiphilic Heparinoids as Potent Antiviral Agents against SARS-CoV-2
    Chhabra, Mohit
    Shanthamurthy, Chethan D.
    Kumar, Nanjudaswamy Vijendra
    Mardhekar, Sandhya
    Vishweshwara, Sharath S.
    Wimmer, Norbert
    Modhiran, Naphak
    Watterson, Daniel
    Amarilla, Alberto A.
    Cha, Jonathan S.
    Beckett, James R.
    De Voss, James J.
    Kayal, Yasmin
    Vlodavsky, Israel
    Dorsett, Lauren R.
    Smith, Raymond A. A.
    Gandhi, Neha S.
    Kikkeri, Raghavendra
    Ferro, Vito
    JOURNAL OF MEDICINAL CHEMISTRY, 2024, 67 (14) : 11885 - 11916
  • [40] An overview on in vitro and in vivo antiviral activity of lactoferrin: its efficacy against SARS-CoV-2 infection
    Rosa, Luigi
    Cutone, Antimo
    Conte, Maria Pia
    Campione, Elena
    Bianchi, Luca
    Valenti, Piera
    BIOMETALS, 2023, 36 (03) : 417 - 436
12345