Antiviral Efficacy of Pralatrexate against SARS-CoV-2

被引：9
|
作者：
Bae, Joon-Yong [1 ]
Lee, Gee Eun [1 ]
Park, Heedo [1 ]
Cho, Juyoung [1 ]
Kim, Jeonghun [1 ]
Lee, Jungmin [1 ]
Kim, Kisoon [1 ]
Kim, Jin Il [1 ,2 ]
Park, Man-Seong [1 ,2 ]
机构：
[1] Korea Univ, Inst Viral Dis, Dept Microbiol, Coll Med, Seoul 02841, South Korea
[2] Korea Univ, Biosafety Ctr, Coll Med, Seoul 02841, South Korea
来源：
BIOMOLECULES & THERAPEUTICS | 2021年 / 29卷 / 03期
基金：
新加坡国家研究基金会;
关键词：
Antiviral; COVID-19; Drug repurposing; SARS-CoV-2;
D O I：
10.4062/biomolther.2021.032
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Novel coronavirus (SARS-CoV-2) has caused more than 100 million confirmed cases of human infectious disease (COVID-19) since December 2019 to paralyze our global community. However, only limited access has been allowed to COVID-19 vaccines and antiviral treatment options. Here, we report the efficacy of the anticancer drug pralatrexate against SARS-CoV-2. In Vero and human lung epithelial Calu-3 cells, pralatrexate reduced viral RNA copies of SARS-CoV-2 without detectable cytotoxicity, and viral replication was successfully inhibited in a dose-dependent manner. In a time-to-addition assay, pralatrexate treatment at almost half a day after infection also exhibited inhibitory effects on the replication of SARS-CoV-2 in Calu-3 cells. Taken together, these results suggest the potential of pralatrexate as a drug repurposing COVID-19 remedy.
引用
收藏
页码：268 / 272
页数：5
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