The rise and fall of compartmental analysis

被引：19

作者：

Rescigno, A

机构：

[1] Stillwater, MN 55082-9278

来源：

PHARMACOLOGICAL RESEARCH | 2001年 / 44卷 / 04期

关键词：

compartmental models; physiological models; AUC; AUMC; tracer kinetics; residence time; exit time; volume of distribution;

D O I：

10.1006/phrs.2001.0873

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The concept of compartment evolved in the contexts of radioactivity, physiology, pharmacology and tracer kinetics. Recently compartmental models have been compared with 'physiological models', C even though in most cases the same, or stricter hypotheses, are necessary for the validity of these latter models. This paper shows that the methods of compartmental analysis are valid only if some specific hypotheses are valid. (C) 2001 Academic Press.

引用

页码：337 / 342

页数：6

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