'Mendelian randomization' equals instrumental variable analysis with genetic instruments

被引：55
|
作者：
Wehby, George L. [1 ]
Ohsfeldt, Robert L. [3 ]
Murray, Jeffrey C. [2 ]
机构：
[1] Univ Iowa, Dept Hlth Management & Policy, Iowa City, IA 52242 USA
[2] Univ Iowa, Coll Med, Dept Pediat, Iowa City, IA 52242 USA
[3] Texas A&M Hlth Sci Ctr, Sch Rural Publ Hlth, College Stn, TX USA
来源：
STATISTICS IN MEDICINE | 2008年 / 27卷 / 15期
关键词：
Mendelian randomization; instrumental variables; endogenous variables; self-selection; confounding;
D O I：
10.1002/sim.3255
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Interest in instrumental variable (IV) analyses using genetic instruments has been growing over the past 4 years. The background, strength and weaknesses of this approach, which in the epidemiology literature has been referred to as 'Mendelian randomization', has been recently reviewed by Lawlor et al. (Statist. Med. 2007. DOI: 10.1002/sim.3034). We suggest a change in the nomenclature of 'Mendelian randomization' and discuss issues relevant to IV analysis including instrument validation, motivation of IV analysis and interpretation of IV estimates in order to motivate a more consistent and standard use of IV analysis across applications using genetic instruments. Copyright (C) 2008 John Wiley & Sons, Ltd.
引用
收藏
页码：2745 / 2749
页数：5
相关论文
共 50 条
  • [1] Is Mendelian randomization 'lost in translation?': Comments on 'Mendelian randomization equals instrumental variable analysis with genetic instruments' by Wehby et al.
    Lawlor, Debbie A.
    Windmeijer, Frank
    Smith, George Davey
    STATISTICS IN MEDICINE, 2008, 27 (15) : 2750 - 2755
  • [2] A review of instrumental variable estimators for Mendelian randomization
    Burgess, Stephen
    Small, Dylan S.
    Thompson, Simon G.
    STATISTICAL METHODS IN MEDICAL RESEARCH, 2017, 26 (05) : 2333 - 2355
  • [3] Bayesian methods for instrumental variable analysis with genetic instruments ('Mendelian randomization'): example with urate transporter SLC2A9 as an instrumental variable for effect of urate levels on metabolic syndrome
    McKeigue, Paul M.
    Campbell, Harry
    Wild, Sarah
    Vitart, Veronique
    Hayward, Caroline
    Rudan, Igor
    Wright, Alan F.
    Wilson, James F.
    INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 2010, 39 (03) : 907 - 918
  • [4] Mendelian randomization as an instrumental variable approach to causal inference
    Didelez, Vanessa
    Sheehan, Nuala
    STATISTICAL METHODS IN MEDICAL RESEARCH, 2007, 16 (04) : 309 - 330
  • [5] Instrumental variable model average with applications in Mendelian randomization
    Seng, Loraine Liping
    Liu, Ching-Ti
    Wang, Jingli
    Li, Jialiang
    STATISTICS IN MEDICINE, 2023, 42 (19) : 3547 - 3567
  • [6] An adjusted instrumental-variable model for Mendelian randomization
    Palmer, T. M.
    Burton, P. R.
    Thompson, J. R.
    Tobin, M. D.
    GENETIC EPIDEMIOLOGY, 2007, 31 (06) : 641 - 641
  • [7] MENDELIAN RANDOMIZATION: THE USE OF GENES IN INSTRUMENTAL VARIABLE ANALYSES
    Scholder, Stephanie von Hinke Kessler
    Smith, George Davey
    Lawlor, Debbie A.
    Propper, Carol
    Windmeijer, Frank
    HEALTH ECONOMICS, 2011, 20 (08) : 893 - 896
  • [8] Consistency and Collapsibility Are They Crucial for Instrumental Variable Analysis with a Survival Outcome in Mendelian Randomization?
    Burgess, Stephen
    EPIDEMIOLOGY, 2015, 26 (03) : 411 - 413
  • [9] Genetic instrumental variable analysis: time to call mendelian randomization what it is. The example of alcohol and cardiovascular disease
    Kenneth J. Mukamal
    Meir J. Stampfer
    Eric B. Rimm
    European Journal of Epidemiology, 2020, 35 : 93 - 97
  • [10] Genetic instrumental variable analysis: time to call mendelian randomization what it is. The example of alcohol and cardiovascular disease
    Mukamal, Kenneth J.
    Stampfer, Meir J.
    Rimm, Eric B.
    EUROPEAN JOURNAL OF EPIDEMIOLOGY, 2020, 35 (02) : 93 - 97
12345