Background: The status characterized by the imbalance between pro-oxidants and antioxidants molecules, defined as oxidative stress, has been suggested to be involved in the pathogenesis of subfertility in females. This study aims to evaluate the impact of a complete micronutrients supplementation on oxidative stress levels in follicular microenvironment as well as on in vitro fertilization (IVF) outcome. Methods: This preliminary study was conducted between January 2014 and July 2015 at the Siena University Hospital Infertility Clinic. Serum and follicular fluid were collected from infertile women aged >39 years who underwent two in vitro fertilization cycles: in the first cycle they were treated with GnRH-antagonist protocol and gonadotropins for controlled ovarian hyperstimulation, whereas in the second cycle ovarian stimulation protocol was associated to micronutrients supplementation, starting three months earlier. Protein oxidation levels and total antioxidant capacity in serum and in follicular fluid were evaluated in IVF cycles with or without micronutrients supplementation. Differences in IVF outcome parameters were statistically evaluated. Results: Two-dimensional electrophoresis analyses demonstrated that when patients assumed micronutrients before IVF cycles, follicular fluid and serum proteins were protected from oxidative damage. Comparable results were obtained when total antioxidant capacity was measured. Moreover, the mean number of good quality oocytes retrieved when patients received micronutrients supplementation was significantly increased. Conclusion: The additional treatment with micronutrients, starting three months before IVF cycles, protects the follicular microenvironment from oxidative stress, thus increasing the number of good quality oocytes recovered at the pick up.
机构:
Nanjing Med Univ, Affiliated Hosp 1, State Key Lab Reprod Med, Nanjing, Jiangsu, Peoples R ChinaNanjing Med Univ, Affiliated Hosp 1, State Key Lab Reprod Med, Nanjing, Jiangsu, Peoples R China
Qian, Y.
Cai, L. B.
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Nanjing Med Univ, Affiliated Hosp 1, State Key Lab Reprod Med, Nanjing, Jiangsu, Peoples R ChinaNanjing Med Univ, Affiliated Hosp 1, State Key Lab Reprod Med, Nanjing, Jiangsu, Peoples R China
Cai, L. B.
Jiang, C. Y.
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Nanjing Med Univ, Affiliated Hosp 1, State Key Lab Reprod Med, Nanjing, Jiangsu, Peoples R ChinaNanjing Med Univ, Affiliated Hosp 1, State Key Lab Reprod Med, Nanjing, Jiangsu, Peoples R China
Jiang, C. Y.
Cui, Y. G.
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Nanjing Med Univ, Affiliated Hosp 1, State Key Lab Reprod Med, Nanjing, Jiangsu, Peoples R ChinaNanjing Med Univ, Affiliated Hosp 1, State Key Lab Reprod Med, Nanjing, Jiangsu, Peoples R China
Cui, Y. G.
Liu, J. Y.
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Nanjing Med Univ, Affiliated Hosp 1, State Key Lab Reprod Med, Nanjing, Jiangsu, Peoples R ChinaNanjing Med Univ, Affiliated Hosp 1, State Key Lab Reprod Med, Nanjing, Jiangsu, Peoples R China
Liu, J. Y.
Meng, Y.
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Nanjing Med Univ, Affiliated Hosp 1, State Key Lab Reprod Med, Nanjing, Jiangsu, Peoples R ChinaNanjing Med Univ, Affiliated Hosp 1, State Key Lab Reprod Med, Nanjing, Jiangsu, Peoples R China
机构:
Univ Fed Rio de Janeiro, IBCCF, Rio de Janeiro, RJ, BrazilUniv Fed Rio de Janeiro, IBCCF, Rio de Janeiro, RJ, Brazil
Pizarro, Bartira M.
Antunes, Roberto A.
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Univ Fed Rio de Janeiro, IBCCF, Rio de Janeiro, RJ, Brazil
Fertipraxis, Rio De Janeiro, RJ, Brazil
Univ Fed Rio de Janeiro, Maternidade Escola, Rio de Janeiro, RJ, BrazilUniv Fed Rio de Janeiro, IBCCF, Rio de Janeiro, RJ, Brazil
Antunes, Roberto A.
Cordeiro, Aline
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Univ Fed Rio de Janeiro, IBCCF, Rio de Janeiro, RJ, BrazilUniv Fed Rio de Janeiro, IBCCF, Rio de Janeiro, RJ, Brazil
Cordeiro, Aline
Mancebo, Ana C. A.
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Fertipraxis, Rio De Janeiro, RJ, BrazilUniv Fed Rio de Janeiro, IBCCF, Rio de Janeiro, RJ, Brazil
Mancebo, Ana C. A.
Bloise, Enrrico
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Univ Fed Rio de Janeiro, IBCCF, Rio de Janeiro, RJ, BrazilUniv Fed Rio de Janeiro, IBCCF, Rio de Janeiro, RJ, Brazil
Bloise, Enrrico
Areas, Patricia C. S.
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Fertipraxis, Rio De Janeiro, RJ, BrazilUniv Fed Rio de Janeiro, IBCCF, Rio de Janeiro, RJ, Brazil
Areas, Patricia C. S.
Souza, Maria C. B.
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Fertipraxis, Rio De Janeiro, RJ, BrazilUniv Fed Rio de Janeiro, IBCCF, Rio de Janeiro, RJ, Brazil
Souza, Maria C. B.
Fortunato, Rodrigo
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Univ Fed Rio de Janeiro, IBCCF, Rio de Janeiro, RJ, BrazilUniv Fed Rio de Janeiro, IBCCF, Rio de Janeiro, RJ, Brazil
Fortunato, Rodrigo
Ortiga-Carvalho, Tania M.
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Univ Fed Rio de Janeiro, IBCCF, Rio de Janeiro, RJ, BrazilUniv Fed Rio de Janeiro, IBCCF, Rio de Janeiro, RJ, Brazil
机构:
SUNY Albany, Dept Environm Hlth Sci, Rensselaer, NY USASUNY Albany, Dept Environm Hlth Sci, Rensselaer, NY USA
Butts, Celeste D.
Bloom, Michael S.
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George Mason Univ, Dept Global & Community Hlth, 4400 Univ Dr,MS 5B7, Fairfax, VA 22030 USASUNY Albany, Dept Environm Hlth Sci, Rensselaer, NY USA
Bloom, Michael S.
McGough, Alexandra
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Univ Calif San Francisco, Dept Obstet Gynecol & Reprod Sci, San Francisco, CA USASUNY Albany, Dept Environm Hlth Sci, Rensselaer, NY USA
McGough, Alexandra
Lenhart, Nikolaus
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Univ Calif San Francisco, Dept Obstet Gynecol & Reprod Sci, San Francisco, CA USASUNY Albany, Dept Environm Hlth Sci, Rensselaer, NY USA
Lenhart, Nikolaus
Wong, Rebecca
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h-index: 0
机构:
Univ Calif San Francisco, Dept Obstet Gynecol & Reprod Sci, San Francisco, CA USASUNY Albany, Dept Environm Hlth Sci, Rensselaer, NY USA
Wong, Rebecca
Mok-Lin, Evelyn
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Univ Calif San Francisco, Dept Obstet Gynecol & Reprod Sci, San Francisco, CA USASUNY Albany, Dept Environm Hlth Sci, Rensselaer, NY USA
Mok-Lin, Evelyn
Parsons, Patrick J.
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SUNY Albany, Dept Environm Hlth Sci, Rensselaer, NY USA
New York State Dept Hlth, Wadsworth Ctr, Lab Inorgan & Nucl Chem, Albany, NY USASUNY Albany, Dept Environm Hlth Sci, Rensselaer, NY USA
Parsons, Patrick J.
Galusha, Aubrey L.
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机构:
SUNY Albany, Dept Environm Hlth Sci, Rensselaer, NY USA
New York State Dept Hlth, Wadsworth Ctr, Lab Inorgan & Nucl Chem, Albany, NY USASUNY Albany, Dept Environm Hlth Sci, Rensselaer, NY USA
Galusha, Aubrey L.
Browne, Richard W.
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SUNY Buffalo, Dept Biotech & Clin Lab Sci, Buffalo, NY USASUNY Albany, Dept Environm Hlth Sci, Rensselaer, NY USA
Browne, Richard W.
Yucel, Recai M.
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机构:
Temple Univ, Dept Epidemiol & Biostat, Philadelphia, PA USASUNY Albany, Dept Environm Hlth Sci, Rensselaer, NY USA
Yucel, Recai M.
Feingold, Beth J.
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机构:
SUNY Albany, Dept Environm Hlth Sci, Rensselaer, NY USASUNY Albany, Dept Environm Hlth Sci, Rensselaer, NY USA
Feingold, Beth J.
Fujimoto, Victor Y.
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机构:
Univ Calif San Francisco, Dept Obstet Gynecol & Reprod Sci, San Francisco, CA USASUNY Albany, Dept Environm Hlth Sci, Rensselaer, NY USA