Lignans with neuroprotective activity from the fruits of Crataegus pinnatifida

被引：7
|
作者：
Xin, Ben-Song [1 ]
Zhao, Peng [1 ]
Qin, Shu-Yan [1 ]
Yao, Guo-Dong [1 ]
Huang, Xiao-Xiao [1 ]
Song, Shao-jiang [1 ]
机构：
[1] Shenyang Pharmaceut Univ, Engn Res Ctr Nat Med Act Mol Res & Dev, Sch Tradit Chinese Mat Med,Key Lab Nat Bioact Cpd, Key Lab Computat Chem Based Nat Antitumor Drug Re, Shenyang 110016, Liaoning, Peoples R China
来源：
FITOTERAPIA | 2022年 / 160卷
关键词：
Crataegus pinnatifida; Lignans; Chiral resolution; Enantiomers; Bioinformatics analysis; Neuroprotective activities; CHEMICAL-CONSTITUENTS; HAWTHORN; NEOLIGNANS; LEAVES; ENANTIOMERS; GLYCOSIDES;
D O I：
10.1016/j.fitote.2022.105216
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Seven lignans (1a/1b-2a/2b and 3-5), including six new compounds (1b, 2a/2b, 3-5), were isolated from the fruits of Crataegus pinnatifida. Their structures were elucidated by comprehensive spectroscopic analyses. Compounds 1b/1b-2a/2b were two pairs of enantiomers and the absolute configurations were determined by comparison of their experimental and calculated ECD spectra. Moreover, bioinformatics analysis suggested that more than a third of diseases were related to the nervous system. Therefore, all compounds were evaluated for neuroprotective effects toward human neumblastoma SH-SY5Y cells injury induced by H2O2. Among them, compound la exhibited moderate protective effect.
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页数：9
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