Lignans with neuroprotective activity from the fruits of Crataegus pinnatifida

被引：7

作者：

Xin, Ben-Song ^{[1
]}

Zhao, Peng ^{[1
]}

Qin, Shu-Yan ^{[1
]}

Yao, Guo-Dong ^{[1
]}

Huang, Xiao-Xiao ^{[1
]}

Song, Shao-jiang ^{[1
]}

机构：

[1] Shenyang Pharmaceut Univ, Engn Res Ctr Nat Med Act Mol Res & Dev, Sch Tradit Chinese Mat Med,Key Lab Nat Bioact Cpd, Key Lab Computat Chem Based Nat Antitumor Drug Re, Shenyang 110016, Liaoning, Peoples R China

来源：

FITOTERAPIA | 2022年 / 160卷

关键词：

Crataegus pinnatifida; Lignans; Chiral resolution; Enantiomers; Bioinformatics analysis; Neuroprotective activities; CHEMICAL-CONSTITUENTS; HAWTHORN; NEOLIGNANS; LEAVES; ENANTIOMERS; GLYCOSIDES;

D O I：

10.1016/j.fitote.2022.105216

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Seven lignans (1a/1b-2a/2b and 3-5), including six new compounds (1b, 2a/2b, 3-5), were isolated from the fruits of Crataegus pinnatifida. Their structures were elucidated by comprehensive spectroscopic analyses. Compounds 1b/1b-2a/2b were two pairs of enantiomers and the absolute configurations were determined by comparison of their experimental and calculated ECD spectra. Moreover, bioinformatics analysis suggested that more than a third of diseases were related to the nervous system. Therefore, all compounds were evaluated for neuroprotective effects toward human neumblastoma SH-SY5Y cells injury induced by H2O2. Among them, compound la exhibited moderate protective effect.

引用

页数：9

共 50 条

[1] Sesquineolignans derivatives with neuroprotective activity from the fruits of Crataegus pinnatifida
Zhao, Peng
Qiu, Shuang
Hou, Zi-Lin
Xue, Xiao-Bian
Yao, Guo-Dong
Huang, Xiao-Xiao
Song, Shao-Jiang
FITOTERAPIA, 2020, 143
[2] Four pair of enantiomeric benzofuran lignans from the fruits of Crataegus pinnatifida bunge
Zhang, Ding-Ding
Zhao, Peng
Huang, Shun-Wang
Song, Shao-Jiang
Huang, Xiao-Xiao
NATURAL PRODUCT RESEARCH, 2023, 37 (08) : 1349 - 1355
[3] Three new sesquineolignans from the fruits of Crataegus pinnatifida
Zhao, Peng
Qiu, Shuang
Yu, Xiao-Qi
Yao, Guo-Dong
Huang, Xiao-Xiao
Song, Shao-Jiang
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2021, 23 (11) : 1051 - 1056
[4] Phytochemical composition, antioxidant activity and neuroprotective effect of Crataegus pinnatifida fruit
Chang, C. L.
Chen, H. S.
Shen, Y. C.
Lai, G. H.
Lin, P. K.
Wang, C. M.
SOUTH AFRICAN JOURNAL OF BOTANY, 2013, 88 : 432 - 437
[5] In vitro antidiabetic potential of the fruits of Crataegus pinnatifida
Chowdhury, S. S.
Islam, M. N.
Jung, H. A.
Choi, J. S.
RESEARCH IN PHARMACEUTICAL SCIENCES, 2014, 9 (01) : 11 - 22
[6] A new dineolignan with anti-β-amyloid aggregation activity from the fruits of crataegus pinnatifida bge
Zhao, Peng
Lou, Li-Li
Zhang, Hao
Guo, Rui
Wang, Xiao-Bo
Huang, Xiao-Xiao
Song, Shao-Jiang
NATURAL PRODUCT RESEARCH, 2021, 35 (12) : 2112 - 2115
[7] New norlignan enantiomers from the fruit of Crataegus pinnatifida with neuroprotective activities
Guo, Rui
Lv, Tianming
Han, Fengying
Hou, Zilin
Yao, Guodong
Lin, Bin
Wang, Xiaobo
Huang, Xiaoxiao
Song, Shaojiang
CHINESE CHEMICAL LETTERS, 2020, 31 (05) : 1254 - 1258
[8] Chiral resolution and neuroprotective activities of enantiomeric 8-O-4′ neolignans from the fruits of Crataegus pinnatifida Bge
Zhao, Peng
Zhang, Hao
Han, Feng-Ying
Guo, Rui
Huang, Shun-Wang
Lin, Bin
Huang, Xiao-Xiao
Song, Shao-Jiang
FITOTERAPIA, 2019, 136
[9] New norlignan enantiomers from the fruit of Crataegus pinnatifida with neuroprotective activities
Rui Guo
Tianming Lv
Fengying Han
Zilin Hou
Guodong Yao
Bin Lin
Xiaobo Wang
Xiaoxiao Huang
Shaojiang Song
ChineseChemicalLetters, 2020, 31 (05) : 1254 - 1258
[10] Seven new neuroprotective sesquineolignans isolated from the seeds of Crataegus pinnatifida
Cheng, Zhuo-Yang
Lou, Li-Li
Yang, Pei-Yuan
Songa, Xiao-Yu
Wang, Xiao-Bo
Huang, Xiao-Xiao
Song, Shao-Jiang
FITOTERAPIA, 2019, 133 : 225 - 230

← 1 2 3 4 5 →