Omega-3 fatty acids in anti-inflammation (pro-resolution) and GPCRs

被引：123
|
作者：
Im, Dong-Soon [1 ]
机构：
[1] Pusan Natl Univ, Coll Pharm, Pharmacol Lab, Mol Inflammat Res Ctr Aging Intervent MRCA, Pusan 609735, South Korea
来源：
PROGRESS IN LIPID RESEARCH | 2012年 / 51卷 / 03期
基金：
新加坡国家研究基金会;
关键词：
Omega-3; PPAR gamma; GPR120; Resolvin; Fish oil; GPCR; PROTEIN-COUPLED RECEPTORS; PROLIFERATOR-ACTIVATED RECEPTORS; POLYUNSATURATED FATTY-ACIDS; DOCOSAHEXAENOIC ACID; RESOLVIN D1; PPAR-GAMMA; FISH-OIL; ANTIINFLAMMATORY PROPERTIES; SECONDARY-PREVENTION; ASPIRIN TREATMENT;
D O I：
10.1016/j.plipres.2012.02.003
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Omega-3 fatty acids, such as, DNA and EPA, have well established beneficial effects on human health, but their action mechanisms remain unknown. Recent pharmacological studies have suggested several molecular targets for the anti-inflammatory effects of omega-3 fatty acids, namely, nuclear receptor PPAR gamma and the G protein-coupled receptor GPR120. Furthermore, the conversions of omega-3 fatty acids to anti-inflammatory and pro-resolving resolvins and protectins and the identifications of putative target GPCRs, ChemR23, BLT1, ALX/FPR2, and GPR32, have drawn great attention. In addition, the pharmacology of omega-3 fatty acids is now under scrutiny. However, questions remain to be answered regarding the in vivo effects of omega-3 fatty acids at the molecular level. In this review, anti-inflammatory effects of omega-3 fatty acids are discussed from the viewpoint of molecular pharmacology, particularly with respect to the above-mentioned GPCRs. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：232 / 237
页数：6
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