A MAGE-1 peptide recognized on HLA-DR15 by CD4+ T cells

被引：0
|
作者：
Chaux, P
Lethé, B
Van Snick, J
Corthals, J
Schultz, ES
Cambiaso, CL
Boon, T
van der Bruggen, P
机构：
[1] Ludwig Inst Canc Res, B-1200 Brussels, Belgium
[2] Univ Louvain, Cellular Genet Unit, Brussels, Belgium
[3] Free Univ Brussels, Sch Med, Physiol Lab, B-1000 Brussels, Belgium
[4] Univ Louvain, Expt Med Unit, Brussels, Belgium
来源：
EUROPEAN JOURNAL OF IMMUNOLOGY | 2001年 / 31卷 / 06期
关键词：
MAGE; CD4(+); dendritic cell; tumor immunity; antigen; peptide; epitope;
D O I：
10.1002/1521-4141(200106)31:6<1910::AID-IMMU1910>3.0.CO;2-K
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Antigens encoded by MAGE genes and recognized by T cells are of interest for cancer immunotherapy because of their strict tumoral specificity and because they are shared by many tumors. Several MAGE-1 peptide that are recognized by CD8(+) cytolytic T lymphocytes have been used in therapeutic vaccination trials. To obtain anti-tumor immune response, vaccines combining peptides recognized by CD8(+) and peptides recognized by CD4(+) T cells might be optimal. We focused therefore on the identification of MAGE peptides recognized by CD4(+) T cells. We report here the identification of MAGE-1 epitope EYVIKVSARVRF, which is presented to CD4+ T lymphocytes by HLA-DR15. This HLA allele is present in 29% of Asians and 17% of Caucasians.
引用
收藏
页码：1910 / 1916
页数：7
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