A new class of tight binding non-nucleoside reverse transcriptase inhibitors inhibit the burst and steady-state phases of wild-type and Y188L HIV-1 reverse transcriptase activity

被引:0
|
作者
Leveque, V. [1 ]
Giannetti, Tony [1 ]
Li, Y. [1 ]
Deval, J. [1 ]
Harris, S. [1 ]
Cammack, N. [1 ]
Klumpp, K. [1 ]
机构
[1] Roche Palo Alto LLC, Palo Alto, CA 94304 USA
关键词
D O I
暂无
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
引用
收藏
页码:A58 / A58
页数:1
相关论文
共 50 条
  • [21] Insights into Biophysical Methods to Study Interactions Between HIV-1 Reverse Transcriptase and Non-nucleoside Reverse Transcriptase Inhibitors
    Dumond, Julien
    Tronchet, Jean-Marcel J.
    Serge, Kirkiacharian
    Seman, Michel
    Reboud-Ravaux, Michele
    LETTERS IN DRUG DESIGN & DISCOVERY, 2020, 17 (06) : 818 - 825
  • [22] Benzophenone derivatives of pyrimidines as effective non-nucleoside inhibitors of wild-type and drug-resistant HIV-1 reverse transcriptase
    Prokofjeva, M. M.
    Valuev-Elliston, V. T.
    Ivanov, A. V.
    Kochetkov, S. N.
    Novikov, M. S.
    Prassolov, V. S.
    DOKLADY BIOCHEMISTRY AND BIOPHYSICS, 2012, 447 (01) : 280 - 281
  • [23] Benzophenone derivatives of pyrimidines as effective non-nucleoside inhibitors of wild-type and drug-resistant HIV-1 reverse transcriptase
    M. M. Prokofjeva
    V. T. Valuev-Elliston
    A. V. Ivanov
    S. N. Kochetkov
    M. S. Novikov
    V. S. Prassolov
    Doklady Biochemistry and Biophysics, 2012, 447 : 280 - 281
  • [24] Docking study of non-nucleoside inhibitors of HIV-1 reverse transcriptase.
    Zhou, ZG
    Madrid, M
    Madura, J
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2002, 223 : U465 - U465
  • [25] Lead Optimization of Diarylpyrimidines as Non-nucleoside Inhibitors of HIV-1 Reverse Transcriptase
    Zeng, Zhao-Sen
    Liang, Yong-Hong
    Feng, Xiao-Qing
    Chen, Fen-Er
    Pannecouque, Christophe
    Balzarini, Jan
    De Clercq, Erik
    CHEMMEDCHEM, 2010, 5 (06) : 837 - 840
  • [26] Rational Design of Potent Non-Nucleoside Inhibitors of HIV-1 Reverse Transcriptase
    Chong, Pek
    Sebahar, Paul
    Youngman, Michael
    Garrido, Dulce
    Zhang, Huichang
    Stewart, Eugene L.
    Nolte, Robert T.
    Wang, Liping
    Ferris, Robert G.
    Edelstein, Mark
    Weaver, Kurt
    Mathis, Amanda
    Peat, Andrew
    JOURNAL OF MEDICINAL CHEMISTRY, 2012, 55 (23) : 10601 - 10609
  • [27] The synthesis of several tritiated non-nucleoside, HIV-1 reverse transcriptase inhibitors
    Hamill, Terence G.
    Brenner, Nancy J.
    Eng, Wai-Si
    Burns, H. Donald
    Journal of Labelled Compounds and Radiopharmaceuticals, 1998, 41 (04): : 319 - 327
  • [28] Arylsulfone-based HIV-1 non-nucleoside reverse transcriptase inhibitors
    Famiglini, Valeria
    Coluccia, Antonio
    Brancale, Andrea
    Pelliccia, Sveva
    La Regina, Giuseppe
    Silvestri, Romano
    FUTURE MEDICINAL CHEMISTRY, 2013, 5 (18) : 2141 - 2156
  • [29] In silico screening of HIV-1 non-nucleoside reverse transcriptase and protease inhibitors
    Leitao, Andrei
    Andricopulo, Adriano D.
    Montanari, Carlos A.
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2008, 43 (07) : 1412 - 1422
  • [30] Systematic Investigation of Non-Nucleoside Inhibitors of HIV-1 Reverse Transcriptase (NNRTIs)
    Anton Beyer
    Luckhana Lawtrakul
    Supa Hannongbua
    Peter Wolschann
    Monatshefte für Chemie / Chemical Monthly, 2004, 135 : 1047 - 1059