Why do cells have multiple error-prone DNA polymerases?

被引：26
|
作者：
Friedberg, EC [1 ]
机构：
[1] Univ Texas, SW Med Ctr, Dept Pathol, Lab Mol Pathol, Dallas, TX 75390 USA
来源：
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS | 2001年 / 38卷 / 2-3期
关键词：
error-prone DNA polymerises; UV radiation; E; coli; prokaryotic cells; eukaryotic cells;
D O I：
10.1002/em.1059
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
Recent years have witnessed the emergence of a plethora of so-called novel DNA polymerases in both eukaryotic and prokaryotic cells. Many of these DNA polymerases are characterized by poor replicational fidelity and low processivity, and are devoid of 3 ' --> 5 ' exonuclease activity. This article describes the discovery of these error-prone polymerases and what is known about their biological function. Environ. Mol. Mutagen. (C) 2001 Wiley-Liss, Inc.
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收藏
页码：105 / 110
页数：6
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