Posttreatment exacerbation of hepatitis B virus (HBV) infection in long-term HBV trials of emtricitabine

被引：19
|
作者：
Mondou, E [1 ]
Sorbel, J [1 ]
Anderson, J [1 ]
Mommeja-Marin, H [1 ]
Rigney, A [1 ]
Rousseau, F [1 ]
机构：
[1] Gilead Sci Inc, Durham, NC 27707 USA
来源：
CLINICAL INFECTIOUS DISEASES | 2005年 / 41卷 / 05期
关键词：
D O I：
10.1086/432581
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Posttreatment exacerbation of hepatitis B virus (HBV) infection in long-term HBV trials of emtricitabine occurred in 23% of patients. Development of antibody to hepatitis e antigen did not prevent hepatic flare. One patient with marked bridging fibrosis required liver transplantation. Patients with advanced liver disease are at risk for hepatic flare with decompensation if active treatment is withdrawn (e.g., when highly active antiretroviral treatment is modified).
引用
收藏
页码：E45 / E47
页数：3
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