Mesenchymal stem cells derived secretome as an innovative cell-free therapeutic approach

被引：1
|
作者：
Abu-El-Rub, Ejlal [1 ,2 ]
Khasawneh, Ramada R. [1 ]
Almahasneh, Fatimah A. [1 ]
Zegallai, Hana M. [3 ,4 ]
机构：
[1] Yarmouk Univ, Fac Med, Dept Basic Med Sci, Irbid 21163, Jordan
[2] Univ Manitoba, Fac Med, Physiol & Pathophysiol, Winnipeg, MB R3E 0W2, Canada
[3] Univ Manitoba, Dept Pharmacol & Therapeut, Winnipeg, MB R3E 0W2, Canada
[4] Childrens Hosp Res Inst Manitoba, DREAM, Winnipeg, MB R3E 0W2, Canada
来源：
BIOCELL | 2022年 / 46卷 / 04期
关键词：
Mesencyhmal stem cells; Secretome; Immuno-modulation; Cytokines; Growth factors; PARACRINE MECHANISMS;
D O I：
10.32604/biocell.2022.018306
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The paracrine and immunomodulatory cytokines secreted by mesenchymal stem cells (MSCs), generally referred to as the MSCs derived secretome, has substantial potential for the treatment of many chronic and degenerative diseases. MSCs secretome contains both common and disease specific cytokines and modulators that can be beneficial against a wide range of chronic diseases. Herein, we discuss the MSCs secretome composition profile and its translational applicability and the challenges surrounding its use in clinical settings.
引用
收藏
页码：907 / 911
页数：5
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