Synthesis and cytotoxicity evaluation of [(2,4-dichlorophenoxy)methyl]-5-aryl-1,3,4-oxadiazole/4 H-1,2,4-triazole analogues

被引：9
|
作者：
Ahsan, Mohamed Jawed [1 ]
机构：
[1] Maharishi Arvind Coll Pharm, Dept Pharmaceut Chem, Jaipur, Rajasthan, India
来源：
TURKISH JOURNAL OF CHEMISTRY | 2018年 / 42卷 / 05期
关键词：
Anticancer activity; cancer cell lines; cytotoxicity; one dose assay; oxadiazole; triazole; ANTICANCER; POTENT; 1,3,4-OXADIAZOLE; 1,2,4-TRIAZOLES; REPLACEMENTS; OXADIAZOLE; DISCOVERY;
D O I：
10.3906/kim-1803-25
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We report herein the synthesis, characterization, and cytotoxicity evaluations of some newer oxadiazole and triazole analogues (5a-j). The cytotoxicity of all the title compounds were evaluated as per the National Cancer Institute protocol in a one-dose assay (10 mu M) on nine different panels of 59 cancer cell line. 2-{5-[(2,4-Dichlorophenoxy)methyl]-1,3,4-oxadiazol-2-yl} phenol (5e) showed the maximum cytotoxicity among the series of ten compounds. The cytotoxicity of 5e was comparable to that of the standard anticancer drug, 5-fluorouracil, and better than that of imatinib. The structure activity relationship was also discussed.
引用
收藏
页码：1334 / +
页数：18
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